European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

January

ERJ Podcast

January Podcast: ERS guidelines on chronic cough Eur Respir J, 55 (1) 20E5501; 10.1183/13993003.E5501-2020

Editorials

The evolution of the European Respiratory Journal: ready for the new decade! James D. Chalmers, Elin L. Reeves, Neil J. Bullen, Martin Kolb Eur Respir J, 55 (1) 1902503; 10.1183/13993003.02503-2019
Can animal models really teach us anything about pneumonia? Pro Carlos J. Orihuela, Ulrich A. Maus, Jeremy S. Brown Eur Respir J, 55 (1) 1901539; 10.1183/13993003.01539-2019
Can animal models really teach us anything about pneumonia? Con Mark Metersky, Grant Waterer Eur Respir J, 55 (1) 1901525; 10.1183/13993003.01525-2019
ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma Richard Beasley, Irene Braithwaite, Alex Semprini, Ciléin Kearns, Mark Weatherall, Tim W. Harrison, Alberto Papi, Ian D. Pavord Eur Respir J, 55 (1) 1901407; 10.1183/13993003.01407-2019
Current challenges in the management of nonsmall cell lung cancer brain metastases Lizza E.L. Hendriks, Jacques Cadranel, Thierry Berghmans Eur Respir J, 55 (1) 1901686; 10.1183/13993003.01686-2019
Airway mucus accumulation in COPD: the cholinergic paradox! Pierre-Régis Burgel Eur Respir J, 55 (1) 1902473; 10.1183/13993003.02473-2019
Can a better understanding of frailty improve the quality of life of patients with fibrotic interstitial lung diseases? Bernard Aguilaniu Eur Respir J, 55 (1) 1902255; 10.1183/13993003.02255-2019
Integrating high dose inhaled corticosteroids into oral corticosteroids stewardship Arnaud Bourdin, Carey Suehs, Jérémy Charriot Eur Respir J, 55 (1) 1902193; 10.1183/13993003.02193-2019
Single cell analysis of human lung development: knowing what mesenchymal cells are and what they may be Jennifer M.S. Sucre, James Hagood Eur Respir J, 55 (1) 1902327; 10.1183/13993003.02327-2019
Looking at the COPD spectrum through “PRISm” Amin Adibi, Mohsen Sadatsafavi Eur Respir J, 55 (1) 1902217; 10.1183/13993003.02217-2019
Size matters! Peripheral blood leukocyte telomere length and survival after critical illness Florian B. Mayr, Sachin Yende Eur Respir J, 55 (1) 1902114; 10.1183/13993003.02114-2019
Patient reported outcomes for non-tuberculous mycobacterial disease Michael R. Loebinger, Surinder S. Birring Eur Respir J, 55 (1) 1902204; 10.1183/13993003.02204-2019
Respiratory medicine is not gender blind Mina Gaga, Daiana Stolz, Joanna Chorostowska-Wynimko, Tobias Welte, Anita Simonds Eur Respir J, 55 (1) 1901847; 10.1183/13993003.01847-2019

ERS guidelines

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children Alyn H. Morice, Eva Millqvist, Kristina Bieksiene, Surinder S. Birring, Peter Dicpinigaitis, Christian Domingo Ribas, Michele Hilton Boon, Ahmad Kantar, Kefang Lai, Lorcan McGarvey, David Rigau, Imran Satia, Jacky Smith, Woo-Jung Song, Thomy Tonia, Jan W.K. van den Berg, Mirjam J.G. van Manen, Angela Zacharasiewicz Eur Respir J, 55 (1) 1901136; 10.1183/13993003.01136-2019
European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia Liesbeth Duijts, Evelien R. van Meel, Laura Moschino, Eugenio Baraldi, Magda Barnhoorn, Wichor M. Bramer, Charlotte E. Bolton, Jeanette Boyd, Frederik Buchvald, Maria Jesus del Cerro, Andrew A. Colin, Refika Ersu, Anne Greenough, Christiaan Gremmen, Thomas Halvorsen, Juliette Kamphuis, Sailesh Kotecha, Kathleen Rooney-Otero, Sven Schulzke, Andrew Wilson, David Rigau, Rebecca L. Morgan, Thomy Tonia, Charles C. Roehr, Marielle W. Pijnenburg Eur Respir J, 55 (1) 1900788; 10.1183/13993003.00788-2019

ERS/ATS guidelines

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline Fernando Holguin, Juan Carlos Cardet, Kian Fan Chung, Sarah Diver, Diogenes S. Ferreira, Anne Fitzpatrick, Mina Gaga, Liz Kellermeyer, Sandhya Khurana, Shandra Knight, Vanessa M. McDonald, Rebecca L. Morgan, Victor E. Ortega, David Rigau, Padmaja Subbarao, Thomy Tonia, Ian M. Adcock, Eugene R. Bleecker, Chris Brightling, Louis-Philippe Boulet, Michael Cabana, Mario Castro, Pascal Chanez, Adnan Custovic, Ratko Djukanovic, Urs Frey, Betty Frankemölle, Peter Gibson, Dominique Hamerlijnck, Nizar Jarjour, Satoshi Konno, Huahao Shen, Cathy Vitary, Andy Bush Eur Respir J, 55 (1) 1900588; 10.1183/13993003.00588-2019

COPD and basic science

Excess mucus viscosity and airway dehydration impact COPD airway clearance Vivian Y. Lin, Niroop Kaza, Susan E. Birket, Harrison Kim, Lloyd J. Edwards, Jennifer LaFontaine, Linbo Liu, Marina Mazur, Stephen A. Byzek, Justin Hanes, Guillermo J. Tearney, S. Vamsee Raju, Steven M. Rowe Eur Respir J, 55 (1) 1900419; 10.1183/13993003.00419-2019

Tuberculosis

A regimen containing bedaquiline and delamanid compared to bedaquiline in patients with drug-resistant tuberculosis Olatunde Olayanju, Aliasgar Esmail, Jason Limberis, Keertan Dheda Eur Respir J, 55 (1) 1901181; 10.1183/13993003.01181-2019

Interstitial lung disease

Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema Camila M. Costa, J. Alberto Neder, Carlos G. Verrastro, Marcelle Paula-Ribeiro, Roberta Ramos, Eloara M. Ferreira, Luiz E. Nery, Denis E. O'Donnell, Carlos A.C. Pereira, Jaquelina Ota-Arakaki Eur Respir J, 55 (1) 1901319; 10.1183/13993003.01319-2019
Functional ageing in fibrotic interstitial lung disease: the impact of frailty on adverse health outcomes Sabina A. Guler, Joanne M. Kwan, Janice M. Leung, Nasreen Khalil, Pearce G. Wilcox, Christopher J. Ryerson Eur Respir J, 55 (1) 1900647; 10.1183/13993003.00647-2019

Interstitial lung disease and basic science

A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages Nikita Joshi, Satoshi Watanabe, Rohan Verma, Renea P. Jablonski, Ching-I Chen, Paul Cheresh, Nikolay S. Markov, Paul A. Reyfman, Alexandra C. McQuattie-Pimentel, Lango Sichizya, Ziyan Lu, Raul Piseaux-Aillon, David Kirchenbuechler, Annette S. Flozak, Cara J. Gottardi, Carla M. Cuda, Harris Perlman, Manu Jain, David W. Kamp, G.R. Scott Budinger, Alexander V. Misharin Eur Respir J, 55 (1) 1900646; 10.1183/13993003.00646-2019

Sleep medicine

Circulating plasma exosomes in obstructive sleep apnoea and reverse dipping blood pressure Abdelnaby Khalyfa, David Gozal, Wen-Ching Chan, Jorge Andrade, Bharati Prasad Eur Respir J, 55 (1) 1901072; 10.1183/13993003.01072-2019
Bilateral hypoglossal nerve stimulation for treatment of adult obstructive sleep apnoea Peter R. Eastwood, Maree Barnes, Stuart G. MacKay, John R. Wheatley, David R. Hillman, Xuân-Lan Nguyên, Richard Lewis, Matthew C. Campbell, Boris Pételle, Jennifer H. Walsh, Andrew C. Jones, Carsten E. Palme, Alain Bizon, Nicole Meslier, Chloé Bertolus, Kathleen J. Maddison, Laurent Laccourreye, Guillaume Raux, Katleen Denoncin, Valérie Attali, Frédéric Gagnadoux, Sandrine H. Launois Eur Respir J, 55 (1) 1901320; 10.1183/13993003.01320-2019

Asthma and paediatrics

Acute wheeze-specific gene module shows correlation with vitamin D and asthma medication Shintaro Katayama, Katarina Stenberg Hammar, Kaarel Krjutškov, Elisabet Einarsdottir, Gunilla Hedlin, Juha Kere, Cilla Söderhäll Eur Respir J, 55 (1) 1901330; 10.1183/13993003.01330-2019

Asthma

Characteristics and treatment regimens across ERS SHARP severe asthma registries Job J.M.H. van Bragt, Ian M. Adcock, Elisabeth H.D. Bel, Gert-Jan Braunstahl, Anneke ten Brinke, John Busby, Giorgio W. Canonica, Hui Cao, Kian Fan Chung, Zsuzsanna Csoma, Barbro Dahlén, Elizabeth Davin, Susanne Hansen, Enrico Heffler, Ildiko Horvath, Stephanie Korn, Maxim Kots, Piotr Kuna, Namhee Kwon, Renaud Louis, Vicente Plaza, Celeste Porsbjerg, David Ramos-Barbon, Levi B. Richards, Sabina Škrgat, Jacob K. Sont, Susanne J.H. Vijverberg, Els J.M. Weersink, Valentyna Yasinska, Scott S. Wagers, Ratko Djukanovic, Anke H. Maitland-van der Zee Eur Respir J, 55 (1) 1901163; 10.1183/13993003.01163-2019
Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma Ingrid Maijers, Nethmi Kearns, James Harper, Mark Weatherall, Richard Beasley Eur Respir J, 55 (1) 1901147; 10.1183/13993003.01147-2019

Lung biology

Transcriptional characterisation of human lung cells identifies novel mesenchymal lineage markers Soula Danopoulos, Soumyaroop Bhattacharya, Thomas J. Mariani, Denise Al Alam Eur Respir J, 55 (1) 1900746; 10.1183/13993003.00746-2019

Lung structure and function

Trajectory and mortality of preserved ratio impaired spirometry: the Rotterdam Study Sara Renata Alex Wijnant, Emmely De Roos, Maryam Kavousi, Bruno Hugo Stricker, Natalie Terzikhan, Lies Lahousse, Guy G. Brusselle Eur Respir J, 55 (1) 1901217; 10.1183/13993003.01217-2019

Lung infection and critical care

Peripheral blood leukocyte telomere length is associated with survival of sepsis patients Shuo Liu, Chunxue Wang, Gary Green, Hanjing Zhuo, Kathleen D. Liu, Kirsten N. Kangelaris, Antonio Gomez, Alejandra Jauregui, Kathryn Vessel, Serena Ke, Carolyn Hendrickson, Michael A. Matthay, Carolyn S. Calfee, Lorraine B. Ware, Paul J. Wolters Eur Respir J, 55 (1) 1901044; 10.1183/13993003.01044-2019

Lung infection

Preliminary validation of the NTM Module: a patient-reported outcome measure for patients with pulmonary nontuberculous mycobacterial disease Emily Henkle, Kevin L. Winthrop, Gregory P. Ranches, Wesley Plinke, Hana K. Litvin, Alexandra L. Quittner Eur Respir J, 55 (1) 1901300; 10.1183/13993003.01300-2019
Prognostic factors associated with long-term mortality in 1445 patients with nontuberculous mycobacterial pulmonary disease: a 15-year follow-up study Byung Woo Jhun, Seong Mi Moon, Kyeongman Jeon, O Jung Kwon, Heejin Yoo, Keumhee C. Carriere, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won-Jung Koh Eur Respir J, 55 (1) 1900798; 10.1183/13993003.00798-2019

Back to Basics

Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges Howard H.F. Tang, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye Eur Respir J, 55 (1) 1900844; 10.1183/13993003.00844-2019

ERJ Methods

An RNA-seq primer for pulmonologists Sarah G. Chu, Sergio Poli De Frias, Benjamin A. Raby, Ivan O. Rosas Eur Respir J, 55 (1) 1801625; 10.1183/13993003.01625-2018
Biobanking and cryopreservation of human lung explants for omic analysis Sarah G. Chu, Sergio Poli De Frias, Yuichi Sakairi, Rachel S. Kelly, Robert Chase, Kazuhisa Konishi, Ashley Blau, Ellen Tsai, Konstantin Tsoyi, Robert F. Padera, Lynette M. Sholl, Hilary J. Goldberg, Hari R. Mallidi, Phillip C. Camp, Souheil Y. El-Chemaly, Mark A. Perrella, Augustine M.K. Choi, George R. Washko, Benjamin A. Raby, Ivan O. Rosas Eur Respir J, 55 (1) 1801635; 10.1183/13993003.01635-2018

Research letters

Validation of short- and long-term demographic forecasts using the Canadian Cystic Fibrosis Registry Vanessa Martelli, Jenna Sykes, Pierre-Régis Burgel, Gil Bellis, Adèle Coriati, Sanja Stanojevic, Anne Louise Stephenson Eur Respir J, 55 (1) 1901667; 10.1183/13993003.01667-2019
Subpopulations of cells from bronchoalveolar lavage can predict prognosis in sarcoidosis Pernilla Darlington, Susanna Kullberg, Anders Eklund, Johan Grunewald Eur Respir J, 55 (1) 1901450; 10.1183/13993003.01450-2019
Equal or not? Women hold less prestigious roles at respiratory medicine conferences than men Mayurapriya Raviskanthan, Megan Rees, Jo Douglass, Katherine Sleeman, Irene Higginson, Natasha Smallwood Eur Respir J, 55 (1) 1900701; 10.1183/13993003.00701-2019
Computed tomography assessment of peripheral traction bronchiolectasis: impact of minimal intensity projection Constance de Margerie-Mellon, Lisa Belin, Samia Boussouar, Philippe Khafagy, Marie-Pierre Debray, Kim Levand, Marie-Laure Chabi, Antoine Khalil, Amira Benattia, Dominique Israël-Biet, Bruno Crestani, Hilario Nunes, Jacques Cadranel, Philippe Grenier, Dominique Valeyre, Jean-Marc Naccache, Pierre-Yves Brillet Eur Respir J, 55 (1) 1901388; 10.1183/13993003.01388-2019
Anti-IL5 and anti-IL5Ra therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series Jessica Rademacher, Stefanie Konwert, Jan Fuge, Sabine Dettmer, Tobias Welte, Felix C. Ringshausen Eur Respir J, 55 (1) 1901333; 10.1183/13993003.01333-2019
Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs Elisabeth Arndal, Helle K. Johansen, Janus A.J. Haagensen, Jennifer A. Bartell, Rasmus L. Marvig, Mikkel Alanin, Kasper Aanæs, Niels Høiby, Kim G. Nielsen, Vibeke Backer, Christian von Buchwald Eur Respir J, 55 (1) 1901472; 10.1183/13993003.01472-2019
Obstructive sleep apnoea severity and liver steatosis measured by magnetic resonance imaging Wojciech Trzepizur, Jérôme Boursier, Anna Berréhare, Marc Le Vaillant, Ramaroson Andriantsitohaina, Pierre-Henri Ducluzeau, Séverine Dubois, Samir Henni, Pierre Abraham, Paul Calès, Christophe Aubé, Anita Paisant, Frédéric Gagnadoux Eur Respir J, 55 (1) 1901514; 10.1183/13993003.01514-2019
Latent tuberculosis infection among minor asylum seekers in Denmark Banoo Bakir Ahmad, Kristina Langholz Kristensen, Jonathan Peter Glenthoej, Anja Poulsen, Ann-Gine Bryld, Franziska Grundtvig Huber, Ebbe Munk Andersen, Pernille Ravn Eur Respir J, 55 (1) 1901688; 10.1183/13993003.01688-2019
Long-term effect of CFTR modulator therapy on airway nitric oxide Hartmut Grasemann, Michelle Klingel, Julie Avolio, Carley Prentice, Tanja Gonska, Elizabeth Tullis, Felix Ratjen Eur Respir J, 55 (1) 1901113; 10.1183/13993003.01113-2019
Tiotropium add-on therapy reduces seasonal peaks of asthma worsening in adults with symptomatic severe asthma J. Mark FitzGerald, Roland Buhl, Thomas B. Casale, Branko Jugovic, Liliana Zaremba-Pechmann, David M.G. Halpin Eur Respir J, 55 (1) 1900964; 10.1183/13993003.00964-2019
Zoonotic tuberculosis in humans assessed by next-generation sequencing: an 18-month nationwide study in Lebanon Salam El Achkar, Christine Demanche, Marwan Osman, Rayane Rafei, Mohamad Bachar Ismail, Cyril Gaudin, Stéphanie Duthoy, Frédérique De Matos, Hiam Yaacoub, Claire Pinçon, Monzer Hamze, Philip Supply Eur Respir J, 55 (1) 1900513; 10.1183/13993003.00513-2019

Correspondence

Should oral anticoagulation be discontinued after 3 months in the setting of a first high-risk pulmonary embolism secondary to a major transient/reversible risk factor? Hans Slabbynck, Johan Clukers, Daniella Galdermans Eur Respir J, 55 (1) 1902028; 10.1183/13993003.02028-2019
Should oral anticoagulation be discontinued after 3 months in the setting of a first high-risk pulmonary embolism secondary to a major transient/reversible risk factor? Guy Meyer, Stavros Konstantinides Eur Respir J, 55 (1) 1902323; 10.1183/13993003.02323-2019
Is it time to give up on “self-management” of COPD exacerbations? Sanjay Ramakrishnan, Mona Bafadhel Eur Respir J, 55 (1) 1902102; 10.1183/13993003.02102-2019
It is time to further expand research in tailoring self-management of COPD exacerbations! Anke Lenferink, Job van der Palen, Paul D.L.P.M. van der Valk, Morton G. Burt, Peter A. Frith, Marjolein G.J. Brusse-Keizer, Tanja W. Effing Eur Respir J, 55 (1) 1902225; 10.1183/13993003.02225-2019
What kind of emphasis do we need in clinical research to enable personalised respiratory medicine? Igor Gonda Eur Respir J, 55 (1) 1901866; 10.1183/13993003.01866-2019
Connected real-life research, a pillar of P4 medicine Nicolas Roche, Antonio Anzueto, Sinthia Bosnic Anticevich, Alan Kaplan, Marc Miravitlles, Dermot Ryan, Joan B. Soriano, Omar Usmani, Nikos Papadopoulos, G. Walter Canonica Eur Respir J, 55 (1) 1902287; 10.1183/13993003.02287-2019
Prognostic significance of chronic respiratory symptoms in individuals with normal spirometry Ghassan Hamad, Alan Rigby, Alyn H. Morice Eur Respir J, 55 (1) 1902093; 10.1183/13993003.02093-2019
Prognostic significance of chronic respiratory symptoms in individuals with normal spirometry Yunus Çolak, Shoaib Afzal Eur Respir J, 55 (1) 1902226; 10.1183/13993003.02226-2019

Acknowledgement

European Respiratory Journal, list of peer reviewers 2019 Eur Respir J, 55 (1) 2015501; 10.1183/13993003.15501-2020

Author Correction

“ERS and tobacco harm reduction.” Charlotta Pisinger, Elif Dagli, Filippos T. Filippidis, Linnea Hedman, Christer Janson, Stelios Loukides, Sofia Ravara, Isabel Saraiva and Jørgen Vestbo, the ERS Tobacco Control Committee, on behalf of the ERS. Eur Respir J 2019; 54: 1902009. Eur Respir J, 55 (1) 1952009; 10.1183/13993003.52009-2019

Erratum

“Clinical phenotypes and outcomes of precapillary pulmonary hypertension of sickle cell disease.” Laurent Savale, Anoosha Habibi, François Lionnet, Bernard Maitre, Vincent Cottin, Xavier Jais, Ari Chaouat, Elise Artaud-Macari, Matthieu Canuet, Grégoire Prevot, Christelle Chantalat-Auger, David Montani, Olivier Sitbon, Fréderic Galacteros, Gérald Simonneau, Florence Parent, Pablo Bartolucci and Marc Humbert. Eur Respir J 2019; 54: 1900585. Eur Respir J, 55 (1) 1950843; 10.1183/13993003.50585-2019