Source: Eur Respir J, 55 (1) 1900646; 10.1183/13993003.00646-2019
Disease area: Interstitial lung diseases



Rating:

Share or cite this content

Citations should be made in the following way:
Nikita Joshi, Satoshi Watanabe, Rohan Verma, Renea P. Jablonski, Ching-I Chen, Paul Cheresh, Nikolay S. Markov, Paul A. Reyfman, Alexandra C. McQuattie-Pimentel, Lango Sichizya, Ziyan Lu, Raul Piseaux-Aillon, David Kirchenbuechler, Annette S. Flozak, Cara J. Gottardi, Carla M. Cuda, Harris Perlman, Manu Jain, David W. Kamp, G.R. Scott Budinger, Alexander V. Misharin. A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages. Eur Respir J, 55 (1) 1900646; 10.1183/13993003.00646-2019

Member's Comments

No comment yet.

Related content which might interest you: M2 polarized alveolar macrophages in pulmonary fibrosis Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms Year: 2005 Resident alveolar macrophages mediate early alveolar epithelial death signaling and dysfunction Source: Annual Congress 2012 - Novel mechanisms of acute lung injury Year: 2012 Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages Source: Eur Respir J 2006; 28: 486-495 Year: 2006 Collagen VI-producing macrophages mediate lung fibrosis Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair Year: 2019 Collagen itself perpetuates fibrotic remodeling via its immune-stimulating role upon alveolar macrophages and CCL18 production Source: Eur Respir J 2006; 28: Suppl. 50, 604s Year: 2006 Increased production of caspase-1 by alveolar macrophages in patients with pulmonary sarcoidosis Source: Eur Respir J 2002; 20: Suppl. 38, 585s Year: 2002 Increased SDF-1alpha production from alveolar macrophages in sarcoidosis in vitro Source: Annual Congress 2008 - Sarcoidosis: pathophysiology and severity Year: 2008 CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages Source: Eur Respir J, 51 (3) 1702120; 10.1183/13993003.02120-2017 Year: 2018 Temporal patterns of gene expression in alveolar epithelial cells exposed to profibrotic stimuli; paradigms for pulmonary fibrosis Source: Eur Respir J 2004; 24: Suppl. 48, 98s Year: 2004 CX3CR1–fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases Source: Eur Respir J, 55 (2) 1900460; 10.1183/13993003.00460-2019 Year: 2020 Preferential activation of alveolar macrophages versus epithelial cells during initiation of ventilator-induced lung injury in mice Source: Annual Congress 2011 - Lung cell injury and repair Year: 2011 Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema Source: Eur Respir J 2014; 43: 82-91 Year: 2004 Fas-mediated lung injury is independent of resident alveolar macrophages Source: Eur Respir J 2007; 30: Suppl. 51, 444s Year: 2007 IL-11 promotes pulmonary vascular remodeling and lung fibrosis through the activation of endothelial to mesenchymal transition. Source: Virtual Congress 2020 – Translational aspects of idiopathic pulmonary fibrosis Year: 2020 High expression of telomerase/endothelin-1 increase replication and activation of vascular myofibroblasts in usual interstitial pneumonia/idiopathic pulmonary fibrosis Source: Annual Congress 2010 - Pathogenesis of diffuse parenchymal lung disease Year: 2010 Increased haemosiderin-laden alveolar macrophages in IPF patients Source: Annual Congress 2010 - Usefulness of bronchoalveolar lavage in diffuse parenchymal lung disease Year: 2010 Alveolar epithelial injury and apoptosis Source: Annual Congress 2007 - Mechanisms in pulmonary fibrosis Year: 2007 Bleomycin induces cellular senescence in alveolar epithelial cells Source: Eur Respir J 2003; 22: 436-443 Year: 2003 Altered proliferation of alveolar epithelial cells is involved in progressive elastase-induced emphysema Source: Annual Congress 2012 - The smoking gun in COPD biology Year: 2012 Development of assays to evaluate inflammasomes’ activity in the peripheral blood and in alveolar macrophages in fibrotic lung diseases Source: International Congress 2018 – Back to basics and translational research in idiopathic interstitial pneumonias Year: 2018