European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

October

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome Luke Y.C. Chen, Ryan L. Hoiland, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon Eur Respir J, 56 (4) 2003006; 10.1183/13993003.03006-2020
Confronting and mitigating the risk of COVID-19 associated pulmonary aspergillosis Darius Armstrong-James, Jonathan Youngs, Tihana Bicanic, Alireza Abdolrasouli, David W. Denning, Elizabeth Johnson, Varun Mehra, Tony Pagliuca, Brijesh Patel, Johanna Rhodes, Silke Schelenz, Anand Shah, Frank L. van de Veerdonk, Paul E. Verweij, P. Lewis White, Matthew C. Fisher Eur Respir J, 56 (4) 2002554; 10.1183/13993003.02554-2020
Modernising case finding for a₁-antitrypsin deficiency by DNA sequencing of COPD patients Mark Quinn, Alice M. Turner Eur Respir J, 56 (4) 2002628; 10.1183/13993003.02628-2020
Pseudomonas and risk factor mitigation for chronic lung allograft dysfunction Allan R. Glanville Eur Respir J, 56 (4) 2001968; 10.1183/13993003.01968-2020
How can we better predict pulmonary blood clots in patients hospitalised for COVID-19? Laurent Bertoletti, Menno V. Huisman Eur Respir J, 56 (4) 2003092; 10.1183/13993003.03092-2020
Pulmonary complications of tyrosine kinase inhibitors in myeloproliferative disorders Manuel J. Richter, Athiththan Yogeswaran, Khodr Tello Eur Respir J, 56 (4) 2002653; 10.1183/13993003.02653-2020
Epidemic and pandemic viral infections: impact on tuberculosis and the lung Catherine Wei Min Ong, Giovanni Battista Migliori, Mario Raviglione, Gavin MacGregor-Skinner, Giovanni Sotgiu, Jan-Willem Alffenaar, Simon Tiberi, Cornelia Adlhoch, Tonino Alonzi, Sophia Archuleta, Sergio Brusin, Emmanuelle Cambau, Maria Rosaria Capobianchi, Concetta Castilletti, Rosella Centis, Daniela M. Cirillo, Lia D'Ambrosio, Giovanni Delogu, Susanna M.R. Esposito, Jose Figueroa, Jon S. Friedland, Benjamin Choon Heng Ho, Giuseppe Ippolito, Mateja Jankovic, Hannah Yejin Kim, Senia Rosales Klintz, Csaba Ködmön, Eleonora Lalle, Yee Sin Leo, Chi-Chiu Leung, Anne-Grete Märtson, Mario Giovanni Melazzini, Saeid Najafi Fard, Pasi Penttinen, Linda Petrone, Elisa Petruccioli, Emanuele Pontali, Laura Saderi, Miguel Santin, Antonio Spanevello, Reinout van Crevel, Marieke J. van der Werf, Dina Visca, Miguel Viveiros, Jean-Pierre Zellweger, Alimuddin Zumla, Delia Goletti Eur Respir J, 56 (4) 2001727; 10.1183/13993003.01727-2020
Changes in respiratory symptoms during 48-week treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies James D. Chalmers, David Cipolla, Bruce Thompson, Angela M. Davis, Anne O'Donnell, Gregory Tino, Igor Gonda, Charles Haworth, Juergen Froehlich Eur Respir J, 56 (4) 2000110; 10.1183/13993003.00110-2020
Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis Martina Oriano, Andrea Gramegna, Leonardo Terranova, Giovanni Sotgiu, Imran Sulaiman, Luca Ruggiero, Laura Saderi, Benjamin Wu, James D. Chalmers, Leopoldo N. Segal, Paola Marchisio, Francesco Blasi, Stefano Aliberti Eur Respir J, 56 (4) 2000769; 10.1183/13993003.00769-2020
Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD Nisha Gupta, Nathalie Gaudreault, Sébastien Thériault, Pei Zhi Li, Cyndi Henry, Miranda Kirby, François Maltais, Wan Tan, Jean Bourbeau, Yohan Bossé Eur Respir J, 56 (4) 2000958; 10.1183/13993003.00958-2020
Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD Priyadarshini Kachroo, Jarrett D. Morrow, Alvin T. Kho, Carrie A. Vyhlidal, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, Dawn L. DeMeo Eur Respir J, 56 (4) 1902347; 10.1183/13993003.02347-2019
Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis Tim Harrison, Giorgio Walter Canonica, Geoffrey Chupp, Jason Lee, Florence Schleich, Tobias Welte, Antonio Valero, Kim Gemzoe, Aoife Maxwell, Sandra Joksaite, Shibing Yang, Peter Howarth, Melissa K. Van Dyke Eur Respir J, 56 (4) 2000151; 10.1183/13993003.00151-2020
Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena Manali Mukherjee, David Felipe Forero, Stephanie Tran, Marie-Eve Boulay, Mylène Bertrand, Anurag Bhalla, Jayant Cherukat, Hajar Al-Hayyan, Anmar Ayoub, Spencer D. Revill, Tanvi Javkar, Katherine Radford, Melanie Kjarsgaard, Chynna Huang, Anna Dvorkin-Gheva, Kjetil Ask, Ronald Olivenstein, Nandini Dendukuri, Catherine Lemiere, Louis-Philippe Boulet, James G. Martin, Parameswaran Nair Eur Respir J, 56 (4) 2000117; 10.1183/13993003.00117-2020
Self-titration of inhaled corticosteroid and ß₂-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial Christina Baggott, Jo Hardy, Jenny Sparks, Mark Holliday, Daniela Hall, Alexandra Vohlidkova, Robert J. Hancox, Mark Weatherall, James Fingleton, Richard Beasley Eur Respir J, 56 (4) 2000170; 10.1183/13993003.00170-2020
Risks for cold frequency vary by sex: role of asthma, age, TLR7 and leukocyte subsets Liisa M. Murray, Stephanie T. Yerkovich, Manuel A. Ferreira, John W. Upham Eur Respir J, 56 (4) 1902453; 10.1183/13993003.02453-2019
Successful Pseudomonas aeruginosa eradication improves outcomes after lung transplantation: a retrospective cohort analysis Benedicte De Muynck, Anke Van Herck, Annelore Sacreas, Tobias Heigl, Janne Kaes, Arno Vanstapel, Stijn E. Verleden, Arne P. Neyrinck, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Katrien Lagrou, Bart M. Vanaudenaerde, Geert M. Verleden, Robin Vos Eur Respir J, 56 (4) 2001720; 10.1183/13993003.01720-2020
Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients Basile Mouhat, Matthieu Besutti, Kevin Bouiller, Franck Grillet, Charles Monnin, Fiona Ecarnot, Julien Behr, Gilles Capellier, Thibaud Soumagne, Sébastien Pili-Floury, Guillaume Besch, Guillaume Mourey, Quentin Lepiller, Catherine Chirouze, François Schiele, Romain Chopard, Nicolas Meneveau Eur Respir J, 56 (4) 2001811; 10.1183/13993003.01811-2020
Identification of potentially undiagnosed patients with nontuberculous mycobacterial lung disease using machine learning applied to primary care data in the UK Orla M. Doyle, Roald van der Laan, Marko Obradovic, Peter McMahon, Flora Daniels, Ashley Pitcher, Michael R. Loebinger Eur Respir J, 56 (4) 2000045; 10.1183/13993003.00045-2020
Towards elimination of childhood and adolescent tuberculosis in the Netherlands: an epidemiological time-series analysis of national surveillance data Fajri Gafar, Taichi Ochi, Natasha van't Boveneind-Vrubleuskaya, Onno W. Akkerman, Connie Erkens, Susan van den Hof, Tjip S. van der Werf, Jan-Willem C. Alffenaar, Bob Wilffert Eur Respir J, 56 (4) 2001086; 10.1183/13993003.01086-2020
CAMPHOR score: patient-reported outcomes are improved by pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension Michael Newnham, Katherine Bunclark, Nisha Abraham, Samantha Ali, Liliana Amaral-Almeida, John E. Cannon, Natalie Doughty, Choo Ng, Anie Ponnaberanam, Karen Sheares, Nicola Speed, Dolores Taboada, Mark Toshner, Steven Tsui, David P. Jenkins, Joanna Pepke-Zaba Eur Respir J, 56 (4) 1902096; 10.1183/13993003.02096-2019
ICU outcomes can be predicted by noninvasive muscle evaluation: a meta-analysis Clément Medrinal, Yann Combret, Roger Hilfiker, Guillaume Prieur, Nadine Aroichane, Francis-Edouard Gravier, Tristan Bonnevie, Olivier Contal, Bouchra Lamia Eur Respir J, 56 (4) 1902482; 10.1183/13993003.02482-2019
A frame of reference for assessing the intensity of exertional dyspnoea during incremental cycle ergometry J. Alberto Neder, Danilo C. Berton, Luiz E. Nery, Wan C. Tan, Jean Bourbeau, Denis E. O'Donnell Eur Respir J, 56 (4) 2000191; 10.1183/13993003.00191-2020
Predicting extubation outcomes using the Heart Rate Characteristics index in preterm infants: a cohort study Mallinath Chakraborty, William John Watkins, Katherine Tansey, William E. King, Sujoy Banerjee Eur Respir J, 56 (4) 1901755; 10.1183/13993003.01755-2019
Pulmonary complications of Bcr-Abl tyrosine kinase inhibitors Jason Weatherald, Louise Bondeelle, Marie-Camille Chaumais, Christophe Guignabert, Laurent Savale, Xavier Jaïs, Olivier Sitbon, Philippe Rousselot, Marc Humbert, Anne Bergeron, David Montani Eur Respir J, 56 (4) 2000279; 10.1183/13993003.00279-2020
Perspectives on neuroinflammation contributing to chronic cough Alexandria K. Driessen, Anna-Claire Devlin, Fionnuala T. Lundy, S. Lorraine Martin, Gerard P. Sergeant, Stuart B. Mazzone, Lorcan P. McGarvey Eur Respir J, 56 (4) 2000758; 10.1183/13993003.00758-2020
Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD Holly R. Keir, Alison Dicker, Mike Lonergan, Megan Crichton, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers Eur Respir J, 56 (4) 2000391; 10.1183/13993003.00391-2020
In vivo demonstration of pulmonary microvascular involvement in COVID-19 using dual-energy computed tomography Salim Si-Mohamed, Nader Chebib, Monica Sigovan, Lea Zumbihl, Ségoléne Turquier, Sara Boccalini, Loic Boussel, Jean-Francois Mornex, Vincent Cottin, Philippe Douek Eur Respir J, 56 (4) 2002608; 10.1183/13993003.02608-2020
Pulmonary interstitial glycogenosis cells express mesenchymal stem cell markers Csaba Galambos, Eric Wartchow, Jason P. Weinman, Steven H. Abman Eur Respir J, 56 (4) 2000853; 10.1183/13993003.00853-2020
Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid Simone H.J. van den Elsen, Onno W. Akkerman, Mireille Wessels, Erwin M. Jongedijk, Samiksha Ghimire, Tjip S. van der Werf, Mathieu S. Bolhuis, Daan J. Touw, Jan-Willem C. Alffenaar Eur Respir J, 56 (4) 2000803; 10.1183/13993003.00803-2020
Does chemotherapy reactivate SARS-CoV-2 in cancer patients recovered from prior COVID-19 infection? Jianping Bi, Hong Ma, Dongsheng Zhang, Jing Huang, Dongqin Yang, Yajie Wang, Vivek Verma, Tao Zhang, Desheng Hu, Qi Mei, Guang Han, Jian Li Eur Respir J, 56 (4) 2002672; 10.1183/13993003.02672-2020
Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study Stefano Aliberti, Dejan Radovanovic, Filippo Billi, Giovanni Sotgiu, Matteo Costanzo, Tommaso Pilocane, Laura Saderi, Andrea Gramegna, Angelo Rovellini, Luca Perotto, Valter Monzani, Pierachille Santus, Francesco Blasi Eur Respir J, 56 (4) 2001935; 10.1183/13993003.01935-2020
Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation Stefano Belli, Bruno Balbi, Ilaria Prince, Davide Cattaneo, Francesca Masocco, Sergio Zaccaria, Luca Bertalli, Francesco Cattini, Arianna Lomazzo, Francesca Dal Negro, Marica Giardini, Frits M.E. Franssen, Daisy J.A. Janssen, Martijn A. Spruit Eur Respir J, 56 (4) 2002096; 10.1183/13993003.02096-2020
Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study Michele Mondoni, Giuseppe Francesco Sferrazza Papa, Rocco Rinaldo, Paola Faverio, Almerico Marruchella, Francesca D'Arcangelo, Alberto Pesci, Simone Pasini, Sonia Henchi, Giuseppe Cipolla, Francesco Tarantini, Lisa Giuliani, Fabiano Di Marco, Laura Saracino, Stefano Tomaselli, Angelo Corsico, Stefano Gasparini, Martina Bonifazi, Lina Zuccatosta, Laura Saderi, Giulia Pellegrino, Matteo Davì, Paolo Carlucci, Stefano Centanni, Giovanni Sotgiu Eur Respir J, 56 (4) 2002767; 10.1183/13993003.02767-2020
Limited role for bronchoalveolar lavage to exclude COVID-19 after negative upper respiratory tract swabs: a multicentre study Pietro Geri, Francesco Salton, Lina Zuccatosta, Mario Tamburrini, Marco Biolo, Annalisa Busca, Mario Santagiuliana, Umberto Zuccon, Paola Confalonieri, Barbara Ruaro, Pierlanfranco D'Agaro, Stefano Gasparini, Marco Confalonieri Eur Respir J, 56 (4) 2001733; 10.1183/13993003.01733-2020
Difficult to treat microorganisms in patients aged over 80 years with community-acquired pneumonia: the prevalence of PES pathogens Catia Cilloniz, Cristina Dominedo, Héctor José Peroni, Pierluigi Di Giannatale, Carolina Garcia-Vidal, Albert Gabarrus, Adamanthia Liapikou, Adrian Ceccato, Antoni Torres Eur Respir J, 56 (4) 2000773; 10.1183/13993003.00773-2020
Ambulatory treatment of low-risk pulmonary embolism in fragile patients: a subgroup analysis of the multinational Home Treatment of Pulmonary Embolism (HoT-PE) Trial Lukas Hobohm, Toni Anušic, Stavros V. Konstantinides, Stefano Barco Eur Respir J, 56 (4) 2000663; 10.1183/13993003.00663-2020
An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter Gwyneth Davies, Sanja Stanojevic, Emma Raywood, Julie A. Duncan, Janet Stocks, Sooky Lum, Andrew Bush, Laura Viviani, Angie Wade, Alistair Calder, Catherine M. Owens, Christophe Goubau, Siobhán B. Carr, Cara J. Bossley, Caroline Pao, Paul Aurora Eur Respir J, 56 (4) 2000006; 10.1183/13993003.00006-2020
Airway abundance of Haemophilus influenzae predicts response to azithromycin in adults with persistent uncontrolled asthma Steven L. Taylor, Kerry L. Ivey, Peter G. Gibson, Jodie L. Simpson, Geraint B. Rogers Eur Respir J, 56 (4) 2000194; 10.1183/13993003.00194-2020
The Factor V Leiden variant and risk of chronic thromboembolic pulmonary hypertension Mark W. Dodson, Kelli Sumner, Jadyn Carlsen, Meghan M. Cirulis, Emily L. Wilson, Abhishek Gadre, Timothy M. Fernandes, Lynette M. Brown, D. Hunter Best, C. Gregory Elliott Eur Respir J, 56 (4) 2000774; 10.1183/13993003.00774-2020
Electronic cigarettes for smoking cessation: an opportunity to readdress smoking cessation treatment Paraskevi A. Katsaounou Eur Respir J, 56 (4) 2000098; 10.1183/13993003.00098-2020
E-cigarettes for smokers trying to quit Serena Tonstad Eur Respir J, 56 (4) 2002934; 10.1183/13993003.02934-2020
The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region Chen-Yuan Chiang, Tauhid Islam, Caihong Xu, Thilaka Chinnayah, Anna Marie Celina Garfin, Kalpeshsinh Rahevar, Mario Raviglione Eur Respir J, 56 (4) 2003054; 10.1183/13993003.03054-2020
Endothelial to mesenchymal transition: a precursor to post-COVID-19 interstitial pulmonary fibrosis and vascular obliteration? Mathew Suji Eapen, Wenying Lu, Archana Vijay Gaikwad, Prem Bhattarai, Collin Chia, Ashutosh Hardikar, Greg Haug, Sukhwinder Singh Sohal Eur Respir J, 56 (4) 2003167; 10.1183/13993003.03167-2020
Correlation and causality: a COVID-19 conundrum Alyn H. Morice Eur Respir J, 56 (4) 2003174; 10.1183/13993003.03174-2020
A cuckoo COVID coincidence? James D. Chalmers, Mike Lonergan Eur Respir J, 56 (4) 2003236; 10.1183/13993003.03236-2020
Technical standards for respiratory oscillometry: test loads for calibration and verification Cindy Thamrin, Raffaele L. Dellacà, Graham L. Hall, David W. Kaczka, Geoffrey N. Maksym, Ellie Oostveen, Shannon J. Simpson, Gregory G. King Eur Respir J, 56 (4) 2003369; 10.1183/13993003.03369-2020
High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion Judith Elshof, Rutger H.J. Hebbink, Marieke L. Duiverman, Rob Hagmeijer Eur Respir J, 56 (4) 2003004; 10.1183/13993003.03004-2020
High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion Jie Li, James B. Fink, Stephan Ehrmann Eur Respir J, 56 (4) 2003136; 10.1183/13993003.03136-2020
Impact of the SARS-CoV-2 epidemic on tuberculosis treatment outcome in Northern Italy Paola Magro, Beatrice Formenti, Valentina Marchese, Maurizio Gulletta, Lina Rachele Tomasoni, Silvio Caligaris, Francesco Castelli, Alberto Matteelli Eur Respir J, 56 (4) 2002665; 10.1183/13993003.02665-2020
Healthcare workers with COVID-19 in Mexico Silvio A. Ñamendys-Silva Eur Respir J, 56 (4) 2002885; 10.1183/13993003.02885-2020
The determination of ventilatory inefficiency at rest in COPD: the expected parameter Iván Caviedes, Rodrigo Soto, Felix Herth Eur Respir J, 56 (4) 2002947; 10.1183/13993003.02947-2020
“Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment.” Jochen Grommes, Mathias Mörgelin and Oliver Soehnlein. Eur Respir J 2012; 40: 416–423 Eur Respir J, 56 (4) 1150910; 10.1183/13993003.50910-2011
“Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative T_LCO working group. Eur Respir J 2017; 50: 1700010. Eur Respir J, 56 (4) 1750010; 10.1183/13993003.50010-2017