Pharmacodynamic effect of benralizumab on blood basophils and serum biomarkers in adults with COPD with sputum eosinophilia
Rene van der Merwe (Cambridge, United Kingdom), Gautam Damera, Christopher Brightling, Eugene Bleecker, Dewei She, Rene Van der Merwe, Christine Ward
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Effect of anti-IL-13 treatment on airway dimensions in severe asthma: Subgroup analysis
Christopher E. Brightling (Leicester, United Kingdom), Christopher E. Brightling, Lars H. Nordenmark, Meena Jain, Edward Piper, Dewei She, Martin Braddock, Gene Colice, Göran Tornling
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Safety and pharmacology of a soluble epoxide hydrolase inhibitor
Aili Lazaar (Blue Bell, United States of America), Aili Lazaar, Lucy Yang, Jon Robertson, Navin Goyal, Rebecca Boardley, Ruth Tal-Singer, Joseph Cheriyan, David Newby, Ian Wilkinson, Ruth Mayer
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Serelaxin is a potent inhibitor of airway contraction and enhances β-adrenoceptor-mediated relaxation
Jane Bourke (Clayton, Australia), Jane Bourke, Maggie Lam, Maria Jelinic, Laura Parry, Simon Royce, Chrishan Samuel
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Duvelisib, a PI3K-δ,γ inhibitor, in subjects with mild asthma
Tess Schmalbach (Cambridge, United States of America), Tess Schmalbach, Rainard Fuhr, Muna Albayaty, Kerstin Allen, Mark Douglas, Joi Dunbar, Justin McLaughlin, Laura Alexander, Charlotte McKee
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Pharmacokinetics of selective PI3Kδ inhibitors after intratracheal instillation in mice
Pawel Gunerka (Lomianki, Poland), Pawel Gunerka, Joanna Hucz-Kalitowska, Pawel Turowski, Marcin Zagozda, Maciej Dziachan, Mariola Sekular, Anna Bujak, Maciej Wieczorek
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Novel, highly potent and selective JAK3 inhibitor disrupting IL-4/IL-13 signaling in asthma therapy
Anna Bujak (Warsaw, Poland), Anna Bujak, Pawel Gunerka, Joanna Lipner, Michal Mroczkiewicz, Bartosz Stypik, Pawel Turowski, Maciej Wieczorek
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QAW039 (fevipiprant) improves lung function and control of asthma symptoms in patients with more severe air flow limitation: A proof-of-concept study
Veit Erpenbeck (Basel, Switzerland), Veit J. Erpenbeck, Todor A. Popov, S. David Miller, Steven F. Weinstein, Sheldon Spector, Baldur Magnusson, Wande Osuntokun, Paul Goldsmith, Markus Weiss, Jutta Beier
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iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma
Anna-Karin Larsson-Callerfelt (Lund, Sweden), Anna-Karin Larsson-Callerfelt, Maria Weitoft, Leif Bjermer, Ellen Tufvesson, Gunilla Westergren-Thorsson
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Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Chung-Wai Chow (Toronto, Canada), Xiaomin Wang, Sepehr Salehi, Jeremy Soctt, Chung-Wai Chow
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Dose-FEV1 modeling to support future development of AZD2115, a dual acting bronchodilator for the treatment of COPD
Ulrika Wählby Hamren (Mölndal, Sweden), Ulrika Wählby Hamrén, Fredrik Öhrn, Ajay Aggarwal
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Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment
Roland Blanqué (Romainville, France), Roland Blanque, Nicolas Desroy, Sonia Dupont, Céline Cottereaux, Alain Monjardet, Emanuelle Wakselman, Wendy Laenen, Vince Russell, Ellen Van der Aar, Reginald Brys, Bertrand Heckmann
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In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588
Coen Wiegman (London, United Kingdom), Coen Wiegman, Ian Adcock, Alan Rothaul, Mark Main, Frazer Morgan
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Suppression of cough-reflex sensitivity by electronic cigarette use: Effect of nicotine
Peter Dicpinigaitis (New York, United States of America), Peter Dicpinigaitis, Alfredo Lee Chang, Alis Dicpinigaitis
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Pre-clinical to clinical potency of AZD7624 in LPS induced TNFa response
Rikard Pehrson (Mölndal, Sweden), Rikard Pehrson, Tove Hegelund, Sofia Lundin, Patel Naimish, Paul Jansson, Danen Cunoosamy
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Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
Adelina Gavrila (Leicester, United Kingdom), Adelina Gavrila, Latifa Chachi, Omar Tliba, Christopher Brightling, Yassine Amrani
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Development of a novel nano-sized carrier system for aeroseol drug delivery (EGE University translational pulmonology research group)
Ceren Türkcan Kayhan (Izmir, Turkey), Ceren Turkcan Kayhan, Raziye Hilal Senay, Esra Feyzioglu, Fulden Zeynep Ural, Ozlem Goksel, Tuncay Goksel, Suleyman Gulcemal, Munevver Erdinc, Sinan Akgol
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New nasal spray stimulates ciliary activity in vitro
Mieke Boon (Wilsele, Belgium), Mieke Boon, Frans Merkus, Martine Jaspers, Mark Jorissen
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