Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression

Chung-Wai Chow (Toronto, Canada), Xiaomin Wang, Sepehr Salehi, Jeremy Soctt, Chung-Wai Chow

Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Session: New targets and modalities for the treatment of asthma and COPD
Session type: Poster Discussion
Number: 2127
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Chung-Wai Chow (Toronto, Canada), Xiaomin Wang, Sepehr Salehi, Jeremy Soctt, Chung-Wai Chow. Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression. Eur Respir J 2015; 46: Suppl. 59, 2127

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


The effect of lipopolysaccharide-contaminated ovalbumin on airway inflammation and remodeling in a chronic murine asthma model
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013


BmTI-A: A serine protease inhibitor attenuates hyperresponsiveness in an experimental model of chronic allergic inflammation in Balb/c mice
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

IL-37 requires IL18Rα and SIGIRR to diminish experimental allergic airway inflammation in mice
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

PI3Kδ inhibition confer efficacy in experimental models of allergic airway inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015


Characteristics of IL-25 and allergen-induced airways fibrosis in a murine model of asthma
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015


Effects of phosphoinositide-3-kinase inhibitors on steroid-insensitive airway inflammation in poly(I:C) and allergen challenged mice
Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Year: 2016


Effect of mast cells degranulation blockade on the inflammatory response outcome in the COPD model
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016


IL33 and TSLP involvements in influenza-induced exacerbation in a murine model of chronic asthma
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

Acid sphingomyelinase deficiency improves lung function in allergen-induced asthma in mice
Source: Annual Congress 2013 –Cell biology and murine models of asthma and inflammation
Year: 2013

LATE-BREAKING ABSTRACT: Inhibition of TRPA1 reduces airway inflammation and airway hyper-responsiveness in a murine model of allergic rhinitis
Source: International Congress 2016 – Novel mechanisms and therapeutic targets in acute and chronic inflammatory disease
Year: 2016


Repeated lipopolysaccharide stimulation causes corticosteroid insensitive inflammation in lung via phosphoinositide-3-kinase δ signaling
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Influenza induced exacerbation is associated with steroid insensitive AHR and pulmonary inflammation in HDM-sensitised mice
Source: International Congress 2016 – Immune responses in the lung
Year: 2016


IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model
Source: International Congress 2015 – Asthma and lung immunology
Year: 2015


Preventative administration of IL-27 improves airway inflammation of ovalbumin –induced asthma mice model via both STAT1 and GADD45γ/p38MAPK pathways
Source: International Congress 2016 – Pharmacological intervention in humans and murine models of asthma
Year: 2016


Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Roflumilast but not dexamethasone or fluticasone reduces neutrophilic airway inflammation and hyperreactivity in a murine influenza-induced asthma exacerbation model
Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Year: 2016

Immunohistochemical study on changes of mast cell populations during allergic airway inflammation in mice using HDM model
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015


D-tryptophan influences allergic airway inflammation and Th2 immune responses
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

BmTI-A, a serine protease inhibitor, reduces the chronic allergic lung inflammation in a mice model
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015