In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588

Coen Wiegman (London, United Kingdom), Coen Wiegman, Ian Adcock, Alan Rothaul, Mark Main, Frazer Morgan

Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Session: New targets and modalities for the treatment of asthma and COPD
Session type: Poster Discussion
Number: 2130
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Coen Wiegman (London, United Kingdom), Coen Wiegman, Ian Adcock, Alan Rothaul, Mark Main, Frazer Morgan. In-vitro evaluation of a new potent, selective pan-Janus kinase (JAK) inhibitor VR588. Eur Respir J 2015; 46: Suppl. 59, 2130

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Novel, highly potent and selective JAK3 inhibitor disrupting IL-4/IL-13 signaling in asthma therapy
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Preclinical characterization of CPL-302-201, a novel, highly potent and selective PI3Kδ inhibitor for the treatment of inflammatory disorders
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Therapeutic potential of CPL-407-105 – Novel potent JAK/STAT pathway inhibitor for the treatment of asthma
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-a and -? selectivity, suppresses COPD inflammation
Source: Eur Respir J, 50 (4) 1700188; 10.1183/13993003.00188-2017
Year: 2017



RP6503, a novel and selective PI3K δ/gamma inhibitor, potentiates the effect of steroids in pre-clinical models of COPD
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation
Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents
Year: 2017



Pharmacological properties of a novel PI3Kd inhibitor, DS-1515
Source: International Congress 2018 – Basic pharmacology
Year: 2018


In vitro and in vivo pharmacological profile of RP6503, a novel dual PI3K Δ/gamma inhibitor, in pulmonary disease systems
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013

Pre-clinical characterization of RP3128, a novel and potent CRAC channel inhibitor for the treatment of respiratory disorders
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


Experience of using Janus kinase inhibitors in COVID-19
Source: Virtual Congress 2021 – Highlights in COVID-19 diagnosis and treatment
Year: 2021



Kinase inhibitors
Source: Annual Congress 2012 - The promise of new drugs for treating asthma and COPD
Year: 2012


Pharmacological characterization of CHI25243, a novel potent inhaled inhibitor of neutrophil elastase
Source: International Congress 2016 – Therapeutic horizons: novel targets and pharmacological models
Year: 2016



In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019


Safety and pharmacology of a soluble epoxide hydrolase inhibitor
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015


Demonstration of anti-inflammatory properties of an inhaled p38 inhibitor AZD7624
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

New drugs for pulmonary hypertension
Source: Eur Respir Mon 2012; 57: 233-246
Year: 2012


The bronchodilatory and anti-inflammatory effect of MT-810, a novel selective phosphodiesterase-4 (PDE4) inhibitor
Source: Eur Respir J 2006; 28: Suppl. 50, 434s
Year: 2006

In vitro pharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery
Source: International Congress 2016 – Novel insights into the treatment of COPD
Year: 2016


Anti-inflammatory effects of the novel PDE4 inhibitor CHF6001 on virus inducible cytokines
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014