Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment

Roland Blanqué (Romainville, France), Roland Blanque, Nicolas Desroy, Sonia Dupont, Céline Cottereaux, Alain Monjardet, Emanuelle Wakselman, Wendy Laenen, Vince Russell, Ellen Van der Aar, Reginald Brys, Bertrand Heckmann

Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Session: New targets and modalities for the treatment of asthma and COPD
Session type: Poster Discussion
Number: 2129
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Roland Blanqué (Romainville, France), Roland Blanque, Nicolas Desroy, Sonia Dupont, Céline Cottereaux, Alain Monjardet, Emanuelle Wakselman, Wendy Laenen, Vince Russell, Ellen Van der Aar, Reginald Brys, Bertrand Heckmann. Pharmacological profile and efficacy of GLPG1690, a novel ATX inhibitor for COPD treatment. Eur Respir J 2015; 46: Suppl. 59, 2129

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
RP6503, a novel and selective PI3K δ/gamma inhibitor, potentiates the effect of steroids in pre-clinical models of COPD
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Pre-clinical to clinical potency of AZD7624 in LPS induced TNFa response
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015


In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


In vivo efficacy of CHF6001, an inhaled PDE4 inhibitor with a wide therapeutic window
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014


Favorable human safety, pharmacokinetics and pharmacodynamics of the autotaxin inhibitor GLPG1690, a potential new treatment in COPD
Source: International Congress 2015 – Advances in the future treatment of COPD
Year: 2015



Prediction of human lung PK for AZD7624, an inhaled P38 inhibitor for the treatment of COPD
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

The effects of clinically relevant reference agents in a mouse model of severe asthma
Source: International Congress 2015 – Advances in the future treatment of severe asthma
Year: 2015


Preclinical characterization of CPL-302-201, a novel, highly potent and selective PI3Kδ inhibitor for the treatment of inflammatory disorders
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

The anti-inflammatory effects of PF03715455 and roflumilast on both cellular and tissue inflammation in a mouse model of COPD
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

LATE-BREAKING ABSTRACT: Inhibition of RC kinase is a novel therapeutic approach for the treatment of COPD and IPF
Source: International Congress 2014 – Latest insights in airway diseases
Year: 2014

BmTI-A, a serine protease inhibitor, reduces the chronic allergic lung inflammation in a mice model
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

In vitro pharmacological characterization of a novel p38α (MAPK14) inhibitor designed for inhaled delivery
Source: International Congress 2016 – Novel insights into the treatment of COPD
Year: 2016


Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

The effects of intra-nasally administered anti-inflammatory compounds in a mouse model of acute COPD exacerbations
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013

Redefining the asthma treatment paradigm using a locally administered dual PI3Kgd inhibitor
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016



Anti-inflammatory effects of the novel phosphodiesterase type 4 inhibitor CHF6001 on COPD alveolar macrophages and lung tissue
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Pharmacological profile of a novel, potent and oral TRPA1 antagonist. Characterization in a preclinical model of induced cough
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

In vitro and in vivo pharmacological profile of RP6503, a novel dual PI3K Δ/gamma inhibitor, in pulmonary disease systems
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013

Efficacy of a novel PI3Kd inhibitor, DS-1515 in animal models of asthma
Source: International Congress 2018 – Novel drug targets for asthma and COPD
Year: 2018