European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

April

Electronic Resources

ERJ April Podcast: Observing dyspnoea in others Eur Respir J, 51 (4) 18E5104; 10.1183/13993003.E5104-2018

Editorials

Pharmacological treatment of COPD: the devil is always in the detail Dave Singh, Peter J. Barnes, Robert Stockley, Maria Victorina Lopez Valera, Claus Vogelmeier, Alvar Agusti Eur Respir J, 51 (4) 1800263; 10.1183/13993003.00263-2018
The disease model: implications for clinical practice Alvar Agusti Eur Respir J, 51 (4) 1800188; 10.1183/13993003.00188-2018
Promoting respiratory public health through epigenetics research: an ERS Environment Health Committee workshop report Erik Melén, Robert Barouki, Maeve Barry, H. Marike Boezen, Barbara Hoffmann, Susanne Krauss-Etschmann, Gerard H. Koppelman, Bertil Forsberg Eur Respir J, 51 (4) 1702410; 10.1183/13993003.02410-2017
Mesenchymal stromal cells and macrophages in sepsis: new insights Maya E. Kotas, Michael A. Matthay Eur Respir J, 51 (4) 1800510; 10.1183/13993003.00510-2018
NETs in pneumonia: is just enough the right amount? Robert D. Gray Eur Respir J, 51 (4) 1800619; 10.1183/13993003.00619-2018
To sleep: perchance to ditch the ventilator Magdy Younes Eur Respir J, 51 (4) 1800624; 10.1183/13993003.00624-2018
Vicarious breathlessness: an inferential perceptual learned transposition process that may not be inconsequential to either patient or caregiver Miriam J. Johnson, David Gozal Eur Respir J, 51 (4) 1800306; 10.1183/13993003.00306-2018
Identifying early pulmonary arterial hypertension in patients with systemic sclerosis Robin Condliffe, Gabor Kovacs Eur Respir J, 51 (4) 1800495; 10.1183/13993003.00495-2018
Chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: to screen or not to screen? Marius M. Hoeper Eur Respir J, 51 (4) 1800440; 10.1183/13993003.00440-2018

Basic science

Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis Razieh Rabani, Allen Volchuk, Mirjana Jerkic, Lindsay Ormesher, Linda Garces-Ramirez, Johnathan Canton, Claire Masterson, Stephane Gagnon, Kate C. Tatham, John Marshall, Sergio Grinstein, John G. Laffey, Katalin Szaszi, Gerard F. Curley Eur Respir J, 51 (4) 1702021; 10.1183/13993003.02021-2017
Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence Gimano D. Amatngalim, Jasmijn A. Schrumpf, Fernanda Dishchekenian, Tinne C.J. Mertens, Dennis K. Ninaber, Abraham C. van der Linden, Charles Pilette, Christian Taube, Pieter S. Hiemstra, Anne M. van der Does Eur Respir J, 51 (4) 1701009; 10.1183/13993003.01009-2017

Infection

Markers of neutrophil extracellular traps predict adverse outcome in community-acquired pneumonia: secondary analysis of a randomised controlled trial Fahim Ebrahimi, Stavros Giaglis, Sinuhe Hahn, Claudine A. Blum, Christine Baumgartner, Alexander Kutz, Shane Vontelin van Breda, Beat Mueller, Philipp Schuetz, Mirjam Christ-Crain, Paul Hasler Eur Respir J, 51 (4) 1701389; 10.1183/13993003.01389-2017

Interstitial lung disease and rare lung disease

Rates of change in FEV₁ and D_LCO as potential indicators for mTOR inhibitor therapy in premenopausal lymphangioleiomyomatosis patients Angelo M. Taveira-DaSilva, Patricia Julien-Williams, Amanda M. Jones, Mario Stylianou, Joel Moss Eur Respir J, 51 (4) 1702258; 10.1183/13993003.02258-2017

Sleep medicine

Impact of sleep alterations on weaning duration in mechanically ventilated patients: a prospective study Arnaud W. Thille, Faustine Reynaud, Damien Marie, Stéphanie Barrau, Ludivine Rousseau, Christophe Rault, Véronique Diaz, Jean-Claude Meurice, Rémi Coudroy, Jean-Pierre Frat, René Robert, Xavier Drouot Eur Respir J, 51 (4) 1702465; 10.1183/13993003.02465-2017

Pulmonary vascular diseases

Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study Kristian Hellenkamp, Piotr Pruszczyk, David Jiménez, Anna Wyzgal, Deisy Barrios, Michal Ciurzynski, Raquel Morillo, Lukas Hobohm, Karsten Keller, Katarzyna Kurnicka, Maciej Kostrubiec, Rolf Wachter, Gerd Hasenfuß, Stavros Konstantinides, Mareike Lankeit Eur Respir J, 51 (4) 1702037; 10.1183/13993003.02037-2017

Lung cancer

In vivo growth of 60 non-screening detected lung cancers: a computed tomography study Onno M. Mets, Kaman Chung, Pieter Zanen, Ernst T. Scholten, Wouter B. Veldhuis, Bram van Ginneken, Mathias Prokop, Cornelia M. Schaefer-Prokop, Pim A. de Jong Eur Respir J, 51 (4) 1702183; 10.1183/13993003.02183-2017

Breathlessness

Observing dyspnoea in others elicits dyspnoea, negative affect and brain responses Michaela Herzog, Josef Sucec, Ilse Van Diest, Omer Van den Bergh, Cecile Chenivesse, Paul Davenport, Thomas Similowski, Andreas von Leupoldt Eur Respir J, 51 (4) 1702682; 10.1183/13993003.02682-2017

Pulmonary hypertension

Incidence of pulmonary hypertension and determining factors in patients with systemic sclerosis J. Gerry Coghlan, Matthias Wolf, Oliver Distler, Christopher P. Denton, Martin Doelberg, Satenik Harutyunova, Alberto M. Marra, Nicola Benjamin, Christine Fischer, Ekkehard Grünig Eur Respir J, 51 (4) 1701197; 10.1183/13993003.01197-2017
Multicentre observational screening survey for the detection of CTEPH following pulmonary embolism Nicolas Coquoz, Daniel Weilenmann, Daiana Stolz, Vladimir Popov, Andrea Azzola, Jean-Marc Fellrath, Hans Stricker, Alberto Pagnamenta, Sebastian Ott, Silvia Ulrich, Sandor Györik, Jérôme Pasquier, John-David Aubert Eur Respir J, 51 (4) 1702505; 10.1183/13993003.02505-2017
A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels Yanjiang Xing, Shuang Zhao, Qingxia Wei, Shiqiang Gong, Xin Zhao, Fang Zhou, Rafia AI-Lamki, Daniel Ortmann, Mingxia Du, Roger Pedersen, Guangdong Shang, Shuyi Si, Nicholas W. Morrell, Jun Yang Eur Respir J, 51 (4) 1702229; 10.1183/13993003.02229-2017

Asthma

Asthma health services utilisation before, during and after pregnancy: a population-based cohort study Teresa To, Laura Y. Feldman, Jingqin Zhu, Andrea S. Gershon Eur Respir J, 51 (4) 1800209; 10.1183/13993003.00209-2018
Associations between blood eosinophils and decline in lung function among adults with and without asthma Robert J. Hancox, Ian D. Pavord, Malcolm R. Sears Eur Respir J, 51 (4) 1702536; 10.1183/13993003.02536-2017
Multimorbidity medications and poor asthma prognosis Sébastien Chanoine, Margaux Sanchez, Isabelle Pin, Sofia Temam, Nicole Le Moual, Agnès Fournier, Christophe Pison, Jean Bousquet, Pierrick Bedouch, Marie-Christine Boutron-Ruault, Raphaëlle Varraso, Valérie Siroux Eur Respir J, 51 (4) 1702114; 10.1183/13993003.02114-2017
Nonadherence in the era of severe asthma biologics and thermoplasty Joy Lee, Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Anna Mackay, Ryan Hoy, Eli Dabscheck, Robyn O'Hehir, Mark Hew Eur Respir J, 51 (4) 1701836; 10.1183/13993003.01836-2017
Outdoor air pollution, exhaled 8-isoprostane and current asthma in adults: the EGEA study Anaïs Havet, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Morgane Stempfelet, Nino Künzli, Bénédicte Jacquemin, Régis Matran, Rachel Nadif Eur Respir J, 51 (4) 1702036; 10.1183/13993003.02036-2017

Review

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases Alice Huertas, Christophe Guignabert, Joan A. Barberà, Peter Bärtsch, Jahar Bhattacharya, Sunita Bhattacharya, Maria R. Bonsignore, Laurence Dewachter, Anh Tuan Dinh-Xuan, Peter Dorfmüller, Mark T. Gladwin, Marc Humbert, Tom Kotsimbos, Theodoros Vassilakopoulos, Olivier Sanchez, Laurent Savale, Ugo Testa, Martin R. Wilkins Eur Respir J, 51 (4) 1700745; 10.1183/13993003.00745-2017

Research letters

Aspergillus-induced pneumonia in adult without obvious immunodeficiency: test the burst! Héloïse Flament, Vanessa Granger, Corinne Vezinet, Viviana Marzaioli, Caroline Kannengiesser, Luc de Chaisemartin, Margarita Hurtado-Nedelec, Elena Litvinova, Jonathan Messika, Nicolas Adam, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, Renato Monteiro, Jamel el Benna, Olivier Langeron, Sylvie Chollet-Martin, Antoine Monsel Eur Respir J, 51 (4) 1702711; 10.1183/13993003.02711-2017
Role of a clinical prediction score in a chronic thromboembolic pulmonary hypertension rule-out strategy Remedios Otero, Laurent Bertoletti, Alfonso Muriel, Carmine Siniscalchi, Carmen Jimenez, Jose Luis Lobo, Dana Kigitovica, Roberto Quintavalla, Anna Rocci, Luis Jara-Palomares, Manuel Monreal Eur Respir J, 51 (4) 1702576; 10.1183/13993003.02576-2017
Cyclophosphamide in steroid refractory unclassifiable idiopathic interstitial pneumonia and interstitial pneumonia with autoimmune features (IPAF) Ivo A. Wiertz, Coline H.M. van Moorsel, Adriane D.M. Vorselaars, Marian J.R. Quanjel, Jan C. Grutters Eur Respir J, 51 (4) 1702519; 10.1183/13993003.02519-2017
Evaluation of VTE-BLEED for predicting intracranial or fatal bleeding in stable anticoagulated patients with venous thromboembolism Frederikus A. Klok, Stefano Barco, Stavros V. Konstantinides Eur Respir J, 51 (4) 1800077; 10.1183/13993003.00077-2018
Information and education provision in bronchiectasis: co-development and evaluation of a novel patient-driven resource in a digital era Katy L.M. Hester, Julia Newton, Tim Rapley, Vicky Ryan, Anthony De Soyza Eur Respir J, 51 (4) 1702402; 10.1183/13993003.02402-2017
DNA methylation modules in airway smooth muscle are associated with asthma severity Mark M. Perry, Paul Lavender, Chih-hsi Scott Kuo, Francesca Galea, Charalambos Michaeloudes, James M. Flanagan, Kian Fan Chung, Ian M. Adcock Eur Respir J, 51 (4) 1701068; 10.1183/13993003.01068-2017
Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils Frauke Pedersen, Benjamin Waschki, Sebastian Marwitz, Torsten Goldmann, Anne Kirsten, Anna Malmgren, Klaus F. Rabe, Mohib Uddin, Henrik Watz Eur Respir J, 51 (4) 1700970; 10.1183/13993003.00970-2017
Inhaled granulocyte–macrophage colony-stimulating factor for Mycobacterium abscessus in cystic fibrosis John P. Scott, Yinduo Ji, Mathur Kannan, Mark E. Wylam Eur Respir J, 51 (4) 1702127; 10.1183/13993003.02127-2017
The effects of electronic cigarette vapour on the lung: direct comparison to tobacco smoke Viktorija Reinikovaite, Ivan E. Rodriguez, Vijaya Karoor, Aline Rau, Becky B. Trinh, Frederic W-B. Deleyiannis, Laima Taraseviciene-Stewart Eur Respir J, 51 (4) 1701661; 10.1183/13993003.01661-2017
Haemodynamics to predict outcome in pulmonary hypertension due to left heart disease: a meta-analysis Sergio Caravita, Céline Dewachter, Davide Soranna, Sandy Carolino D'Araujo, Amina Khaldi, Antonella Zambon, Gianfranco Parati, Antoine Bondue, Jean-Luc Vachiéry Eur Respir J, 51 (4) 1702427; 10.1183/13993003.02427-2017

Correspondence

To track or not to track: wheeze phenotypes in preschool children Paul L.P. Brand, André Schultz Eur Respir J, 51 (4) 1800042; 10.1183/13993003.00042-2018
Chronic breathlessness: re-thinking the symptom Miriam J. Johnson, Janelle Yorke, John Hansen-Flaschen, Magnus Ekström, David C. Currow Eur Respir J, 51 (4) 1800340; 10.1183/13993003.00340-2018
Adding an invasive procedure will not necessarily change treatment or outcome of NSCLC patients with preoperative clinical N1 disease Alfredo Addeo, Giuseppe Banna Eur Respir J, 51 (4) 1800084; 10.1183/13993003.00084-2018
Adding an invasive procedure will not necessarily change treatment or outcome of NSCLC patients with preoperative clinical N1 disease Herbert Decaluwé, Christophe Dooms, Paul De Leyn, Pascal Thomas, Ramon Rami-Porta Eur Respir J, 51 (4) 1800410; 10.1183/13993003.00410-2018
HypAir F_eNO: an electrochemical sensor Cristina Ramos Hernández, Marta Núñez Fernández, Cecilia Mouronte-Roibas, Mar Mosteiro Añon, Alberto Fernández-Villar Eur Respir J, 51 (4) 1800164; 10.1183/13993003.00164-2018

Author Corrections

“Evolution of respiratory function in Duchenne muscular dystrophy from childhood to adulthood.” Antonella LoMauro, Marianna Romei, Sandra Gandossini, Riccardo Pascuzzo, Simone Vantini, Maria Grazia D'Angelo and Andrea Aliverti. Eur Respir J 2018; 51: 1701418. Eur Respir J, 51 (4) 1751418; 10.1183/13993003.51418-2017
“Sleep apnoea is associated with major cardiac events in peripheral arterial disease.” Karri T. Utriainen, Juhani K. Airaksinen, Olli Polo, Ruut Laitio, Mikko J. Pietilä, Harry Scheinin, Tero Vahlberg, Kari A. Leino, Erkki S. Kentala, Jouko R. Jalonen, Harri Hakovirta, Riitta Parkkola, Sami Virtanen and Timo T. Laitio. Eur Respir J 2014; 43: 1652-1660. Eur Respir J, 51 (4) 1351309; 10.1183/13993003.51309-2013
“Long-term benefits of airway clearance in bronchiectasis: a randomised placebo-controlled trial.” Gerard Muñoz, Javier de Gracia, Maria Buxó, Antonio Alvarez and Montserrat Vendrell. Eur Respir J 2018; 51: 1701926. Eur Respir J, 51 (4) 1751926; 10.1183/13993003.51926-2017