ERJ Open Research

The journal was created to help fulfil the ERS objective to disseminate scientific and educational material to its members and to the medical community, but also to provide researchers with an affordable open access specialty journal in which to publish their work.

October

Study protocols

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol Caroline Wright, Simon P. Hart, Victoria Allgar, Anne English, Flavia Swan, Judith Dyson, Gerry Richardson, Maureen Twiddy, Judith Cohen, Jamilla Hussain, Miriam Johnson, Ian Hargreaves, Michael G. Crooks ERJ Open Res, 5 (4) 00186-2019; 10.1183/23120541.00186-2019

Clinical effectiveness of once-daily fluticasone furoate/umeclidinium/vilanterol in usual practice: the COPD INTREPID study design Sally Worsley, Neil Snowise, David M.G. Halpin, Dawn Midwinter, Afisi S. Ismaila, Elaine Irving, Leah Sansbury, Maggie Tabberer, David Leather, Chris Compton ERJ Open Res, 5 (4) 00061-2019; 10.1183/23120541.00061-2019

Tuberculosis

Comparison of the QuantiFERON-TB and tuberculin skin test for detection of latent tuberculosis infection in cancer patients in a developing country Javier Leonardo Galindo, Adriana Catalina Galeano, David Alfonso Suarez-Zamora, Ana Milena Callejas, Mónica Patricia Caicedo-Verástegui, Darío Londoño, Luis Gerardo García-Herreros, Aylen Vanessa Ospina-Serrano, Alfredo Saavedra, Plutarco Garcíaherreros, Diana María Palacios, Margarita Baldión ERJ Open Res, 5 (4) 00258-2018; 10.1183/23120541.00258-2018
Time to diagnosis of tuberculosis is greater in older patients: a retrospective cohort review Aula Abbara, Simon M. Collin, Onn M. Kon, Kevin Buell, Adam Sullivan, Jessica Barrett, Tumena Corrah, Alastair McGregor, Trevor Hansel, Laurence John, Robert N. Davidson ERJ Open Res, 5 (4) 00228-2018; 10.1183/23120541.00228-2018
EBUS-TBNA in the rapid microbiological diagnosis of drug-resistant mediastinal tuberculous lymphadenopathy Prashant N. Chhajed, Preyas J. Vaidya, Neha P. Mandovra, Vinod B. Chavhan, Tejashree T. Lele, Rekha Nair, Jörg D. Leuppi, Avinandan Saha ERJ Open Res, 5 (4) 00008-2019; 10.1183/23120541.00008-2019
Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data Debora Pedrazzoli, Katharina Kranzer, H. Lucy Thomas, Maeve K. Lalor ERJ Open Res, 5 (4) 00125-2019; 10.1183/23120541.00125-2019

Methamphetamines and pulmonary disease

Methamphetamine use association with pulmonary diseases: a retrospective investigation of hospital discharges in California from 2005 to 2011 Halley Tsai, Justin Lee, Haley Hedlin, Roham T. Zamanian, Vinicio A. de Jesus Perez ERJ Open Res, 5 (4) 00017-2019; 10.1183/23120541.00017-2019

Bronchiolitis obliterans syndrome

Lung clearance index in detection of post-transplant bronchiolitis obliterans syndrome Madeleine Driskel, Alex Horsley, Laurice Fretwell, Nigel Clayton, Mohamed Al-Aloul ERJ Open Res, 5 (4) 00164-2019; 10.1183/23120541.00164-2019
A randomised single-centre trial of inhaled liposomal cyclosporine for bronchiolitis obliterans syndrome post-lung transplantation Aldo Iacono, Marniker Wijesinha, Keshava Rajagopal, Natalia Murdock, Irina Timofte, Bartley Griffith, Michael Terrin ERJ Open Res, 5 (4) 00167-2019; 10.1183/23120541.00167-2019

Lung imaging

Performance of transbronchial cryobiopsy in eccentrically and adjacently orientated radial endobronchial ultrasound lesions Sze Shyang Kho, Swee Kim Chan, Mei Ching Yong, Siew Teck Tie ERJ Open Res, 5 (4) 00135-2019; 10.1183/23120541.00135-2019

Interstitial lung disease

Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis Maria Jacob, Hélder Novais Bastos, Patrícia Caetano Mota, Natália Melo, Rui Cunha, José Miguel Pereira, Susana Guimarães, Conceição Souto Moura, António Morais ERJ Open Res, 5 (4) 00203-2019; 10.1183/23120541.00203-2019
Incidence, comorbidity and survival rate of hypersensitivity pneumonitis: a national population-based study Anne Hald Rittig, Ole Hilberg, Rikke Ibsen, Anders Løkke ERJ Open Res, 5 (4) 00259-2018; 10.1183/23120541.00259-2018
Gaps in care of patients living with pulmonary fibrosis: a joint patient and expert statement on the results of a Europe-wide survey Catharina C. Moor, Marlies S. Wijsenbeek, Elisabetta Balestro, Davide Biondini, Benjamin Bondue, Vincent Cottin, Ron Flewett, Liam Galvin, Steve Jones, Maria Molina-Molina, Lurdes Planas-Cerezales, Antje Prasse, Helmut Prosch, Anne-Marie Russell, Michel Viegas, Guenther Wanke, Wim Wuyts, Michael Kreuter, Francesco Bonella ERJ Open Res, 5 (4) 00124-2019; 10.1183/23120541.00124-2019
Results of the standard set for pulmonary sarcoidosis: feasibility and multicentre outcomes Nynke A. Kampstra, Paul B. van der Nat, Lea M. Dijksman, Frouke T. van Beek, Daniel A. Culver, Robert P. Baughman, Elisabetta A. Renzoni, Wim Wuyts, Vasilis Kouranos, Pieter Zanen, Marlies S. Wijsenbeek, Marinus J.C. Eijkemans, Douwe H. Biesma, Philip J. van der Wees, Jan C. Grutters ERJ Open Res, 5 (4) 00094-2019; 10.1183/23120541.00094-2019
miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri ERJ Open Res, 5 (4) 00138-2019; 10.1183/23120541.00138-2019

Cystic fibrosis

Variable agreement between wearable heart rate monitors during exercise in cystic fibrosis Madeline Gaynor, Abbey Sawyer, Sue Jenkins, Jamie Wood ERJ Open Res, 5 (4) 00006-2019; 10.1183/23120541.00006-2019
Simultaneous sulfur hexafluoride and nitrogen multiple-breath washout (MBW) to examine inherent differences in MBW outcomes Katie J. Bayfield, Alex Horsley, Eric Alton, Samantha Irving, Andrew Bush, Jane C. Davies ERJ Open Res, 5 (4) 00234-2018; 10.1183/23120541.00234-2018
Impact of Achromobacter xylosoxidans isolation on the respiratory function of adult patients with cystic fibrosis Macha Tetart, Frederic Wallet, Maeva Kyheng, Sylvie Leroy, Thierry Perez, Olivier Le Rouzic, Benoit Wallaert, Anne Prevotat ERJ Open Res, 5 (4) 00051-2019; 10.1183/23120541.00051-2019

Asthma

Prevalence of oral corticosteroid use in the German severe asthma population Christian Taube, Peter Bramlage, Annette Hofer, Dörte Anderson ERJ Open Res, 5 (4) 00092-2019; 10.1183/23120541.00092-2019
FASE-CPHG study: a panoramic snapshot of difficult-to-treat, severe asthma in French nonacademic hospitals Laurent Portel, Eric Parrat, Cécilia Nocent-Ejnaini, Gilles Mangiapan, Anne Prud'homme, Jean-Philippe Oster, Corinne Aperre de Vecchi, Cyril Maurer, Chantal Raherison, Didier Debieuvre ERJ Open Res, 5 (4) 00069-2019; 10.1183/23120541.00069-2019
Real-life effectiveness of omalizumab in difficult-to-treat versus severe asthma: a national cohort study in Belgium Katia M.C. Verhamme, Catherine Lucet, Alain Van Meerhaeghe, Guy G.O. Brusselle, Marie-Laurence Lambert ERJ Open Res, 5 (4) 00253-2018; 10.1183/23120541.00253-2018
Sex differences in health services and medication use among older adults with asthma Teresa To, Natasha Gray, Kandace Ryckman, Jingqin Zhu, Ivy Fong, Andrea Gershon ERJ Open Res, 5 (4) 00242-2019; 10.1183/23120541.00242-2019
Efficacy of azithromycin in severe asthma from the AMAZES randomised trial Peter G. Gibson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guy B. Marks, Melissa Baraket, Heather Powell, Jodie L. Simpson ERJ Open Res, 5 (4) 00056-2019; 10.1183/23120541.00056-2019

Bronchiectasis

Recommendations for travelling with bronchiectasis: a joint ELF/EMBARC/ERN-Lung collaboration Michal Shteinberg, Barbara Crossley, Tal Lavie, Sima Nadler, Jeanette Boyd, Felix C. Ringshausen, Tim Aksamit, James D. Chalmers, Pieter Goeminne ERJ Open Res, 5 (4) 00113-2019; 10.1183/23120541.00113-2019
Predictors of non-cystic fibrosis bronchiectasis in Indigenous adult residents of central Australia: results of a case–control study Lloyd Einsiedel, Hai Pham, Virginia Au, Saba Hatami, Kim Wilson, Tim Spelman, Hubertus Jersmann ERJ Open Res, 5 (4) 00001-2019; 10.1183/23120541.00001-2019

Lung transplantation

Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies Charlotte Bry, Dominique Hubert, Martine Reynaud-Gaubert, Claire Dromer, Hervé Mal, Antoine Roux, Véronique Boussaud, Johanna Claustre, Jérôme Le Pavec, Muriel Murris-Espin, Isabelle Danner-Boucher ERJ Open Res, 5 (4) 00254-2018; 10.1183/23120541.00254-2018

COPD

Behavioural interventions targeting physical activity improve psychocognitive outcomes in COPD Kim L. Lavoie, Maria Sedeno, Alan Hamilton, Pei-Zhi Li, Dorothy De Sousa, Thierry Troosters, François Maltais, Jean Bourbeau ERJ Open Res, 5 (4) 00013-2019; 10.1183/23120541.00013-2019
Isolating peripheral effects of endogenous opioids in modulating exertional breathlessness in people with moderate or severe COPD: a randomised controlled trial David C. Currow, Toby Hunt, Sandra Louw, Danny Eckert, Peter Allcroft, Tim H.M. To, Aine Greene, Malgorzata Krajnik, Don Mahler, Magnus Ekström ERJ Open Res, 5 (4) 00153-2019; 10.1183/23120541.00153-2019

Respiratory infections

Changing epidemiology of nontuberculous mycobacterial lung disease over the last two decades in a region of the Basque country Sandra Pedrero, Eva Tabernero, Eunate Arana-Arri, Elena Urra, Maialen Larrea, Rafael Zalacain ERJ Open Res, 5 (4) 00110-2018; 10.1183/23120541.00110-2018
Association of atypical antipsychotics and mortality for patients hospitalised with pneumonia Zachary Boivin, Mario F. Perez, Nkiruka C. Atuegwu, Mark Metersky, Carlos A. Alvarez, Antonio Anzueto, Eric M. Mortensen ERJ Open Res, 5 (4) 00223-2018; 10.1183/23120541.00223-2018

Pulmonary vascular disease

Plasma receptor tyrosine kinase RET in pulmonary arterial hypertension diagnosis and differentiation Joanna Säleby, Habib Bouzina, Salaheldin Ahmed, Jakob Lundgren, Göran Rådegran ERJ Open Res, 5 (4) 00037-2019; 10.1183/23120541.00037-2019

Lung function

Prognostic significance of pulmonary function tests in dyskeratosis congenita, a telomere biology disorder Neelam Giri, Sandhiya Ravichandran, Youjin Wang, Shahinaz M. Gadalla, Blanche P. Alter, Joseph Fontana, Sharon A. Savage ERJ Open Res, 5 (4) 00209-2019; 10.1183/23120541.00209-2019
Comparison of oscillometry devices using active mechanical test loads Ronald J. Dandurand, Jean-Pierre Lavoie, Larry C. Lands, Zoltán Hantos ERJ Open Res, 5 (4) 00160-2019; 10.1183/23120541.00160-2019

Snus and infant birth size

Snus in pregnancy and infant birth size: a mother–child birth cohort study Ina Kreyberg, Katarina Hilde, Karen Eline S. Bains, Kai-Håkon Carlsen, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Christine M. Jonassen, Live S. Nordhagen, Björn Nordlund, Corina S. Rueegg, Katrine D. Sjøborg, Håvard O. Skjerven, Anne C. Staff, Riyas Vettukattil, Karin C. Lødrup Carlsen ERJ Open Res, 5 (4) 00255-2019; 10.1183/23120541.00255-2019

Cough

Efficacy of two dosing schemes of a liquid containing ivy leaves dry extract EA 575 versus placebo in the treatment of acute bronchitis in adults Axel Schaefer, Fanny Ludwig, Bruno M. Giannetti, Michael Bulitta, Anja Wacker ERJ Open Res, 5 (4) 00019-2019; 10.1183/23120541.00019-2019
Prevalence of chronic wet cough and protracted bacterial bronchitis in Aboriginal children Pamela Laird, James Totterdell, Roz Walker, Anne B. Chang, André Schultz ERJ Open Res, 5 (4) 00248-2019; 10.1183/23120541.00248-2019

Pulmonary rehabilitation

Prevalence of comorbidities and impact on pulmonary rehabilitation outcomes Stacey J. Butler, Lok Sze Katrina Li, Lauren Ellerton, Andrea S. Gershon, Roger S. Goldstein, Dina Brooks ERJ Open Res, 5 (4) 00264-2019; 10.1183/23120541.00264-2019

Lung cancer

Tumour growth rate as a tool for response evaluation during PD-1 treatment for non-small cell lung cancer: a retrospective analysis Deirdre M.H.J. ten Berge, Daniel P. Hurkmans, Ilse den Besten, Jeroen S. Kloover, Ron H.J. Mathijssen, Reno J.E.M.A. Debets, Egbert F. Smit, Joachim G.J.V. Aerts ERJ Open Res, 5 (4) 00179-2019; 10.1183/23120541.00179-2019

E-cigarettes

Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries Kameshwar P. Singh, Gina Lawyer, Thivanka Muthumalage, Krishna P. Maremanda, Naushad Ahmad Khan, Samantha R. McDonough, Dongxia Ye, Scott McIntosh, Irfan Rahman ERJ Open Res, 5 (4) 00182-2019; 10.1183/23120541.00182-2019

Original research letters

Occult malignancy underlying a case of “hyperacute” onset of severe pulmonary hypertension Maria Rosaria Gioia, Uberto Maccari, Luca Marchetti, Enivarco Maglioni, Giuseppina Ciarleglio, Valentina Granese, Laura Salerno, Luigi Spagnoli, Ilenia Zanellato, Maria Raffaella Ambrosio, Andrea Bianco, Raffaele Scala ERJ Open Res, 5 (4) 00157-2019; 10.1183/23120541.00157-2019
Effect of facial skin cooling induced by a handheld fan on the cough reflex threshold and urge to cough induced by citric acid Masashi Kanezaki, Satoru Ebihara ERJ Open Res, 5 (4) 00089-2019; 10.1183/23120541.00089-2019
Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air Orestes A. Carpaij, Susan Muiser, Alex J. Bell, Huib A.M. Kerstjens, Craig J. Galban, Aleksa B. Fortuna, Salman Siddiqui, Anna-Carin Olin, Martijn C. Nawijn, Maarten van den Berge ERJ Open Res, 5 (4) 00202-2019; 10.1183/23120541.00202-2019
Occupational exposures and asthma–COPD overlap in a clinical cohort of adult-onset asthma Minna Tommola, Pinja Ilmarinen, Leena E. Tuomisto, Lauri Lehtimäki, Hannu Kankaanranta ERJ Open Res, 5 (4) 00191-2019; 10.1183/23120541.00191-2019
De novo bronchiectasis in haematological malignancies: patient characteristics, risk factors and survival Ricardo J. José, Jocelin Hall, Jeremy S. Brown ERJ Open Res, 5 (4) 00166-2019; 10.1183/23120541.00166-2019
Asthma and body mass definitions affect estimates of association: evidence from a community-based cross-sectional survey Francisca de Castro Mendes, Inês Paciência, João Cavaleiro Rufo, Diana Silva, Pedro Cunha, Mariana Farraia, Luís Delgado, Pedro Moreira, André Moreira ERJ Open Res, 5 (4) 00076-2019; 10.1183/23120541.00076-2019
Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses Ashwini Rajasekaran, Daniel He, Alice Yue, Amrit Singh, Casey P. Shannon, J. Mark FitzGerald, Louis-Philippe Boulet, Paul M. O'Byrne, Gail M. Gauvreau, Scott J. Tebbutt ERJ Open Res, 5 (4) 00107-2019; 10.1183/23120541.00107-2019
A systematic evaluation of the diagnostic criteria for COPD and exacerbations used in randomised controlled trials on the management of COPD exacerbations Alexander G. Mathioudakis, Julie Janner, Mia Moberg, Pablo Alonso-Coello, Jørgen Vestbo ERJ Open Res, 5 (4) 00136-2019; 10.1183/23120541.00136-2019
The obesity paradox in pulmonary arterial hypertension: the Scottish perspective Luke Lawson McLean, Katherine Pellino, Melanie Brewis, Andrew Peacock, Martin Johnson, Alistair Colin Church ERJ Open Res, 5 (4) 00241-2019; 10.1183/23120541.00241-2019
Rapid and sustained airway control in metastatic malignant melanoma: a case report Sarah Cullivan, John Bruzzi, Teresa McHale, Ramadan Shatwan, Paul Donnellan, David P. Breen ERJ Open Res, 5 (4) 00050-2019; 10.1183/23120541.00050-2019
Suppression of FENO with observed inhaled corticosteroid therapy in severe asthma: is it a useful test in clinical practice? Shoaib Faruqi, Sean Zhou, Joanne Thompson, Terry Robinson, Karen Watkins, Helena Cummings, Nicola Jackson, Anoop Prakash, Michael Crooks ERJ Open Res, 5 (4) 00123-2019; 10.1183/23120541.00123-2019
Serum levels of L1-ORF1p and airflow limitation Stefano Guerra, Monica M. Vasquez, Pasano Bojang, Irma N. Ramos, Duane L. Sherrill, Fernando D. Martinez, Marilyn Halonen, Kenneth S. Ramos ERJ Open Res, 5 (4) 00247-2018; 10.1183/23120541.00247-2018
Factors predicting progression of exercise training loads in people with interstitial lung disease Atsuhito Nakazawa, Leona M. Dowman, Narelle S. Cox, Christine F. McDonald, Catherine J. Hill, Annemarie L. Lee, Anne E. Holland ERJ Open Res, 5 (4) 00245-2018; 10.1183/23120541.00245-2018
Understanding the mechanism of bronchial thermoplasty using airway volume assessed by computed tomography David Langton, Peter B. Noble, Frank Thien, Graham M. Donovan ERJ Open Res, 5 (4) 00272-2019; 10.1183/23120541.00272-2019

Correspondence

SAPS3-CNIV score to predict hospital mortality following noninvasive ventilation: methodology insights Jun Duan, Bushra Mina, Antonio M. Esquinas ERJ Open Res, 5 (4) 00143-2019; 10.1183/23120541.00143-2019