miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation

Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri

Source: ERJ Open Res, 5 (4) 00138-2019; 10.1183/23120541.00138-2019
Journal Issue: October
Disease area: Interstitial lung diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Silvia Moimas, Francesco Salton, Beata Kosmider, Nadja Ring, Maria C. Volpe, Karim Bahmed, Luca Braga, Michael Rehman, Simone Vodret, Maria Laura Graziani, Marla R. Wolfson, Nathaniel Marchetti, Thomas J. Rogers, Mauro Giacca, Gerard J. Criner, Serena Zacchigna, Marco Confalonieri. miR-200 family members reduce senescence and restore idiopathic pulmonary fibrosis type II alveolar epithelial cell transdifferentiation. ERJ Open Res, 5 (4) 00138-2019; 10.1183/23120541.00138-2019

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis
Source: Eur Respir J 2011; 37: 79-87
Year: 2011



Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis
Source: Eur Respir J 2001; 17: 180-189
Year: 2001



Bleomycin induces cellular senescence in alveolar epithelial cells
Source: Eur Respir J 2003; 22: 436-443
Year: 2003



Wnt-inducible protein (WISP-1) is a key regulator of alveolar epithelial cell hyperplasia in pulmonary fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 147s
Year: 2006

Wnt-inducible protein (WISP-1) is a key regulator of alveolar epithelial cell hyperplasia in pulmonary fibrosis
Source: Eur Respir Rev 2006; 15: 180-181
Year: 2006



Alveolar epithelial injury and apoptosis
Source: Annual Congress 2007 - Mechanisms in pulmonary fibrosis
Year: 2007

PP207 – Targeting p16INK4a in alveolar type 2 cells to induce endogenous lung alveolar regeneration
Source: ERS Lung Science Conference 2021
Year: 2021

LSC Abstract – Activation of FGF9 and 18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair
Source: Eur Respir J 2004; 24 : 664-673
Year: 2004



Club cells inhibit alveolar epithelial wound repair via TRAIL-dependent apoptosis
Source: Eur Respir J 2013; 41: 683-694
Year: 2013



Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFβ1-induced fibroblast differentiation into myofibroblasts
Source: Annual Congress 2009 - From emphysema to fibrosis: mechanisms of cellular remodelling in the diseased lung
Year: 2009

Do characteristic airway epithelial change precede the development of lung fibrosis? Ectopic epithelial marker protein expression in bleomycin induced fibrosis replicates that seen in bronchiolized epithelium in IPF
Source: Annual Congress 2012 - Cell culture and animal models of lung disease
Year: 2012

Induction of mesenchymal cell phenotypes in lung epithelial cells by adenovirus E1A
Source: Eur Respir J 2006; 28: 1106-1117
Year: 2006



Alveolar type II cells transplantation decrease fibrocyte migration in pulmonary fibrosis
Source: Annual Congress 2013 –Novel mechanisms in lung injury
Year: 2013


Decreased BCL-2 expression in alveolar macrophages of patients with idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Biomarkers in diffuse parenchymal lung disease
Year: 2010


Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

Does endostatin inhibit epithelial repair in idiopathic pulmonary fibrosis?
Source: Eur Respir J 2006; 28: Suppl. 50, 337s
Year: 2006

PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema
Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology
Year: 2019