Few diseases have undergone such transformative changes in the past four decades as cystic fibrosis. Cystic fibrosis has become the first example of the successful development of mutation-specific drugs. These drugs, known as cystic fibrosis transmembrane conductance regulator (CFTR) modulators, which improve the function of the CFTR channel, have been able to advance incrementally the overall positive development of therapeutic options in cystic fibrosis in only the last 10 years [1].