Infant lung function and maternal physical activity in the first half of pregnancy
Hrefna Katrín Gudmundsdóttir, Oda C.L. Carlsen, Karen Eline Stensby Bains, Martin Färdig, Guttorm Haugen, Christine M. Jonassen, Marissa LeBlanc, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Anne Cathrine Staff, Riyas Vettukattil, Karin C. Lødrup Carlsen
Source: ERJ Open Res, 8 (4) 00172-2022; 10.1183/23120541.00172-2022
Abstract
Background and aim
Physical activity (PA) in pregnancy is important for maternal and possibly offspring health. To study the early origins of lung function we aimed to determine whether PA in the first half of pregnancy is associated with lung function in healthy 3-month-old infants.
Methods
From the general population-based Preventing Atopic Dermatitis and Allergies in Children birth cohort recruiting infants antenatally in Norway and Sweden, all 812 infants (48.8% girls) with available tidal flow–volume measures in the awake state at 3 months of age and mid-pregnancy data on PA were included. PA was self-reported by the mothers and, based on intensity, we categorised them as active or inactive during pregnancy. Furthermore, we defined active mothers as fairly or highly active. The main outcome was a ratio of time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25. Associations were analysed by logistic regression, adjusting for maternal age, education, parity, pre-pregnancy body mass index, in utero nicotine exposure and parental atopy.
Results
The mean±sd tPTEF/tE was 0.391±0.08 and did not differ significantly according to maternal PA level in pregnancy. The 290 infants of inactive mothers had higher odds of having tPTEF/tE <0.25 compared to infants of all active mothers (OR 2.07, 95% CI 1.13–3.82; p=0.019) and compared to infants (n=224) of fairly active (OR 2.83, 95% CI 1.26–7.24; p=0.018) but not highly active mothers (n=298).
Conclusion
Based on self-reported maternal PA in the first half of pregnancy, 3-month-old infants of inactive compared to active mothers had higher odds of a low tPTEF/tE.
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Hrefna Katrín Gudmundsdóttir, Oda C.L. Carlsen, Karen Eline Stensby Bains, Martin Färdig, Guttorm Haugen, Christine M. Jonassen, Marissa LeBlanc, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Anne Cathrine Staff, Riyas Vettukattil, Karin C. Lødrup Carlsen. Infant lung function and maternal physical activity in the first half of pregnancy. ERJ Open Res, 8 (4) 00172-2022; 10.1183/23120541.00172-2022
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