MSC extracellular vesicles modulate human macrophages in ARDS towards anti-inflammatory phenotype via transfer of miRNA181-a and PTEN-pSTAT5-SOCS1 signalling

Y. Su (Belfast (Northern Ireland), United Kingdom), D. Simpson (Belfast (Northern Ireland), United Kingdom), C. O'Kane (Belfast (Northern Ireland), United Kingdom), D. Brazil (Belfast (Northern Ireland), United Kingdom), A. Krasnodembskaya (Belfast (Northern Ireland), United Kingdom)

Source: Virtual Congress 2021 – Cellular and molecular involvement in lung injury and repair
Session: Cellular and molecular involvement in lung injury and repair
Session type: Oral Presentation
Number: 2695

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Su (Belfast (Northern Ireland), United Kingdom), D. Simpson (Belfast (Northern Ireland), United Kingdom), C. O'Kane (Belfast (Northern Ireland), United Kingdom), D. Brazil (Belfast (Northern Ireland), United Kingdom), A. Krasnodembskaya (Belfast (Northern Ireland), United Kingdom). MSC extracellular vesicles modulate human macrophages in ARDS towards anti-inflammatory phenotype via transfer of miRNA181-a and PTEN-pSTAT5-SOCS1 signalling. 2695

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PAR-2 mediated interactions between mast cells and fibroblasts cause a switch in fibroblast morphology and cytokine profile
Source: International Congress 2019 – New mechanistic insights into pulmonary fibrosis
Year: 2019

Extracellular ATP triggers and maintains airway inflammation in human and murine models of asthma by activating dendritic cells
Source: Annual Congress 2008 - New mechanisms in the pathogenesis of asthma and its response to treatment
Year: 2008


Composition of the cellular matrix, nutrition, and hypoxia modulate the secretion and activation of collagenases and their inhibitors in human lung cells
Source: Eur Respir J 2001; 18: Suppl. 33, 244s
Year: 2001

Differential expression of the S1P transporter, Spinster homologue 2 (Spns2), in airway epithelial cells and macrophages may drive defective macrophage function in COPD
Source: International Congress 2017 – Cigarette smoke and particulate matter: basic science and clinical aspects
Year: 2017

Nintedanib prevents IL-6-mediated secretion of CCL-18 in alternatively activated macrophages and transition of fibroblasts to myofibroblasts
Source: International Congress 2017 – Cellular signalling pathways in pulmonary fibrosis
Year: 2017

Eosinophils contribute to extracellular matrix remodeling by enhancing pulmonary fibroblasts proliferation, differentiation and extracellular matrix proteins production in asthma
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018

Targeted NF-κB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking model
Source: Annual Congress 2009 - Inflammatory cells and cytokines
Year: 2009


Activation of TLR3 augments myofibroblasts differentiation and extracellular matrix production
Source: Annual Congress 2009 - Lung cell biology and immunology
Year: 2009



Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of anti-fibrotic miR-142-3p
Source: Virtual Congress 2020 – Biomarkers and mechanistic aspects of idiopathic pulmonary fibrosis
Year: 2020


Anionic surfactant phospholipids modulate Mycoplasma pneumoniae-induced inflammatory response from alveolar macrophages and U937 cells
Source: Annual Congress 2009 - Mechanisms of infection: what's new?
Year: 2009


Role of EPAC in transmission of ß-adrenoceptor- and EP2-receptor-induced antiproliferative effects in human pulmonary fibroblasts
Source: Annual Congress 2007 - Recent advances in airway smooth muscle biology
Year: 2007



Mesenchymal stromal cells (MSC) anti-microbial effect in acute respiratory distress syndrome (ARDS) is mediated in part by enhanced alveolar macrophage phagocytosis through cell contact-dependent mitochondrial transfer leading to improved macrophage bioenergetics
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016


The maturation of dendritic cells mediated by a polyvalent mechanical bacterial lysate (PBML) results in the secretion of cytokines inducing an anti-bacterial polarization of the locoregional immune-response
Source: Eur Respir J 2004; 24: Suppl. 48, 357s
Year: 2004

AMP affects intracellular Ca2+ signalling, migration, cytokine secretion and T-cell priming capacity of human dendritic cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Eosinophil cationic protein stimulates TGF-β1 release by human lung fibroblasts
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
Source: Annual Congress 2012 - Diffuse parenchymal lung disease I
Year: 2012

LSC - 2019 - Neutrophil-derived microvesicles are internalised by lung epithelial cells and induce inflammatory activation
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019

Extracellular vesicles derived from mesenchymal stem cells prevent pulmonary vascular dysfunction induced by lipopolysaccharide (LPS).
Source: International Congress 2018 – Experimental research in pulmonary hypertension
Year: 2018

The intracellular thioredoxin system mediates inflammatory activation of human lung microvascular endothelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 223s
Year: 2003

Soluble biglycan promotes ovalbumin induced airway inflammation by modulating dendritic cell function in mice
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019