TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?

Rebecca Clarke, Kevin Monaghan, Imad About, Caoimhin S. Griffin, Gerard P. Sergeant, Ikhlas El Karim, J. Graham McGeown, S. Louise Cosby, Timothy M. Curtis, Lorcan P. McGarvey, Fionnuala T. Lundy

Source: Eur Respir J, 50 (3) 1700995; 10.1183/13993003.00995-2017
Journal Issue: September
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Rebecca Clarke, Kevin Monaghan, Imad About, Caoimhin S. Griffin, Gerard P. Sergeant, Ikhlas El Karim, J. Graham McGeown, S. Louise Cosby, Timothy M. Curtis, Lorcan P. McGarvey, Fionnuala T. Lundy. TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?. Eur Respir J, 50 (3) 1700995; 10.1183/13993003.00995-2017

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The effect of pain conditioning on experimentally evoked cough: evidence of impaired endogenous inhibitory control mechanisms in refractory chronic cough
Source: Eur Respir J, 56 (6) 2001387; 10.1183/13993003.01387-2020
Year: 2020



The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury.
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019

Characterisation of TRPA1 activation on sensory nerves
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



Chronic cough: ATP, afferent pathways and hypersensitivity
Source: Eur Respir J, 54 (1) 1900889; 10.1183/13993003.00889-2019
Year: 2019



TRPV4 and activation of airway sensory nerves: The role of ATP
Source: International Congress 2015 – Novel targets and strategies for the treatment of cough, asthma, rhinosinusitis and COPD
Year: 2015

Airway reactivity and neuroimmune relationships in animal model of air born irritants induced symptoms – Role of trigeminal TRPA1 channels
Source: Annual Congress 2012 - Indoor and outdoor air pollution
Year: 2012

Anti-tussive effects of FAAH inhibition: The role of endocannabinoids and downstream signalling pathways in the inhibition of vagal sensory nerve activation
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

EP2 & EP4 receptor agonists inhibit the airway sensory nerves that cause cough, a potential protective control that is lost in human smokers and a pre-clinical COPD model
Source: International Congress 2017 – Novel mechanisms and treatments for COPD
Year: 2017



Bidirectional modulation of urge to cough by nasal TRPA1 and TRPM8 agonists in healthy human subjects
Source: Annual Congress 2012 - Treatment of asthma, bronchiectasis and cough: inhaler use
Year: 2012

The role of trigeminal afferents in up-regulation of cough
Source: Annual Congress 2009 - From cough to sound analysis of breathing
Year: 2009


How do cough patterns correlate with novel capsaicin cough challenge parameters?
Source: Virtual Congress 2021 – Exacerbations of chronic respiratory diseases, including SARS-CoV-2
Year: 2021



Late Breaking Abstract - The airway sensory nerve transcriptome: evidence for neuropathic injury following lipopolysaccharide induced lung inflammation.
Source: Virtual Congress 2020 – Inflammatory pathways in chronic airway diseases
Year: 2020


Different alcohols activate airway sensory nerves by a vanilloid receptor 1 (TRPV1) dependent mechanism
Source: Eur Respir J 2003; 22: Suppl. 45, 415s
Year: 2003

Oral presentation: The role of mast cells, IL-13 and TRP channels in a mouse model of chemical-induced airway hyperresponsiveness
Source: Lung Science Conference 2013 - Early origins and mechanisms of chronic lung disease
Year: 2013

Oral presentation: The role of mast cells, IL-13 and TRP channels in a mouse model of chemical-induced airway hyperresponsiveness
Source: Lung Science Conference 2013 - Early origins and mechanisms of chronic lung disease
Year: 2013

Inhibition of sensory nerve activation by cannabinoid receptor activation in a model of gastroesophageal reflux in guinea pig
Source: Eur Respir J 2005; 26: Suppl. 49, 101s
Year: 2005

The expression of TLRs and TRP channel in pulmonary sensory neuron in bleomycin induced fibrosis model.
Source: International Congress 2017 – Lung fibrosis: basic science
Year: 2017


ATP and cough reflex hypersensitivity: a confusion of goals?
Source: Eur Respir J, 50 (1) 1700802; 10.1183/13993003.00802-2017
Year: 2017