Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for the pathogenesis of allergic airways disease

Krupesh Patel (Glen Waverley, Australia), Krupesh Patel, Chrishan Samuel, Simon Royce

Source: International Congress 2016 – Novel mechanisms and treatment modalities in asthma
Session: Novel mechanisms and treatment modalities in asthma
Session type: Poster Discussion
Number: 4891
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Krupesh Patel (Glen Waverley, Australia), Krupesh Patel, Chrishan Samuel, Simon Royce. Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for the pathogenesis of allergic airways disease. Eur Respir J 2016; 48: Suppl. 60, 4891

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Treatment with Syk inhibitors after establishment of disease phenotype in a chronic HDM model of allergic airways inflammation abolishes AHR and attenuates inflammatory mediator expression
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in the mouse
Source: Annual Congress 2013 –Novel drugs for the treatment of asthma and COPD
Year: 2013

Effect of roflumilast on airway remodeling in a murine model of chronic asthma
Source: International Congress 2015 – New models for treating airway diseases
Year: 2015


PI3Kδ inhibition confer efficacy in experimental models of allergic airway inflammation
Source: International Congress 2015 – Immune mechanisms in the human lung
Year: 2015


Lung specific induction of Wnt-1 has a prophylactic and therapeutic effect on the development of an allergic airway disease
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013

IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model
Source: International Congress 2015 – Asthma and lung immunology
Year: 2015


Investigating antioxidant therapy for steroid-resistant asthma
Source: International Congress 2016 – Asthma: mechanisms and biomarkers that promote clinical understanding
Year: 2016

The effect of lipopolysaccharide-contaminated ovalbumin on airway inflammation and remodeling in a chronic murine asthma model
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013


Characterisation of a steroid-insensitive severe asthma model
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

Crucial timing of a viral component exposure to exacerbate allergen-induced asthma
Source: International Congress 2016 – Clinical and molecular studies in asthma
Year: 2016

The effects of clinically relevant reference agents in a mouse model of severe asthma
Source: International Congress 2015 – Advances in the future treatment of severe asthma
Year: 2015


Ciclesonide and tiotropium synergistically inhibit airway eosinophilia in a guinea pig model of chronic asthma
Source: Annual Congress 2013 –Novel mechanisms for established drugs for asthma and COPD management
Year: 2013

Immunomodulatory role of IL-37 in asthma pathogenesis
Source: International Congress 2016 – Immune responses in the lung
Year: 2016

Adipose derived stem cells ameliorate airway inflammation in mouse models of asthma
Source: International Congress 2015 – Asthma and lung immunology
Year: 2015


Characteristics of IL-25 and allergen-induced airways fibrosis in a murine model of asthma
Source: International Congress 2015 – The immunology of allergic airway disease
Year: 2015


Activation of the β-catenin pathway by Wnt-1 treatment suppress inflammation in the mouse model of allergic airway disease
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015


IL33 and TSLP involvements in influenza-induced exacerbation in a murine model of chronic asthma
Source: International Congress 2015 – Advances in asthma and allergy in animal models
Year: 2015

Small airways targeting of inhaled steroids for severe therapy resistant asthma in children
Source: International Congress 2015 – Paediatric asthma and allergy: asthma management
Year: 2015

Dose-dependent differential effects of thrombin in allergic bronchial asthma
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013


A novel inhaled PI3Kδ inhibitor, LAS194223 reduces allergen-induced airway inflammation in rat
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014