What's new in biomarker analysis?

Thematic Poster
Chairs: Clifford Taggart (Belfast, United Kingdom), Sinead Weldon (Belfast, United Kingdom), Manosij Ghosh (Leuven, Belgium), Mazen Al-Alawi (Dublin, Ireland)

LSC Abstract – Increased oxidative stress leads to telomere shortening in children with alpha-1 antitrypsin deficiency Francisco Jose Dasi Fernandez (Valencia, Spain), Sara Pastor, Amparo Escribano, Silvia Castillo, Ana Reula, María Mercedes Navarro-García, Francisco Sanz, Estrella Fernandez-Fabrellas, Pilar Codoñer-Franch, Francisco Jose Dasi Fernandez
Lipid biomarkers predictive of gastro-oesophageal reflux in adult asthma Kamran Tariq (Southampton, United Kingdom), Kamran Tariq, Joost Brandsma, Dominic Burg, Benjamin L. Nicholas, Rene Lutter, Julie Corfield, Kian F. Chung, Peter H. Howarth, Ana R. Sousa, Anthony D. Postle, Peter J. Sterk, Ratko Djukanovic, U-BIOPRED Study Group
Serum microRNA levels in paediatric females versus males with cystic fibrosis Catherine Greene (Dublin, Ireland), Paul McKiernan, Catherine Mooney, David Henshall, Barry Linnane, Paul McNally, Catherine Greene
The relationship between blood eosinophils and bacterial load in COPD patients Umme Kolsum (Manchester, United Kingdom), Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Sarah Thurston, Chris Brightling, Jadwiga Wedzicha, Dave Singh
The National Institute of Health Research Translational Research collaboration in alpha-1-antitrypsin deficiency: The relationship between CT densitometry and the fibrinogen cleavage biomarker Aα-Val360 Diana Crossley (Birmingham, United Kingdom), Diana Crossley, Paul Newby, Rob Stockley
Increased circulating fibrocytes in asthmatic patients with severe OSA Tsai-Yu Wang (Taipei, Taiwan), Tsai-Yu Wang, Yu-Lun Lo, Chun-Hua Wang, Han-Pin Kuo
Receptor for advanced glycation end products contributes to particulate induced lung function loss and hyperreactivity: Mitigating the effects of a single intense particulate exposure Sophia Kwon (New York, United States of America), Sophia Kwon, Erin J. Caraher, Syed H. Haider, George Crowley, Audrey K. Lee, Minah Ebrahim, Mohamed Zedan, David J. Prezant, Ann Marie Schmidt, Anna Nolan
Can NPT be used to distinguish eosinophilic inflammatory phenotypes in COPD? Kirsty Hambleton (Brackley, United Kingdom), Kirsty Hambleton, Catherine Borg, Clare Connolly, Mona Bafadhel
Signalling through the receptor for advanced glycation end products (RAGE) is increased in acute asthma and correlates with symptom severity Asger Bjerregaard (Hillerod, Denmark), Asger Bjerregaard, Celeste Porsbjerg, Lucy Barrett, Ingrid Laing, Siew-Kim Khoo, Markus Fally, Peter Le Souëf, Vibeke Backer, Philip Thompson, Svetlana Baltic
Impairment of leptin/leptin receptor pathway in nasal epithelium from allergic turbinates Andreina Bruno (Palermo, Italy), Andreina Bruno, Antonella Ballacchino, Liboria Siena, Domenica Russo, Salvatore Gallina, Francesco Lorusso, Giuseppina Chiappara, Mark Gjomarkaj, Elisabetta Pace
Influence of smoking on multifunctional membrane surface glycoprotein expression on the surface of T lymphocytes in BAL fluid from patients with pulmonary sarcoidosis Laimute G Jurgauskiene (Vilnius, Lithuania), Laimute G. Jurgauskiene, Radvile Malickaite, Regina Aleksoniene, Stanislava Simanaviciene, Edvardas Danila
Serum levels of 26S proteasome are lover in patients with asthma Zivile Zemeckiene (Kaunas, Lithuania), Zivile Zemeckiene, Edita Gasiuniene, Astra Vitkauskiene
Proinflammatory cytokines and IP-10 differentiate neutrophilic and eosinophilic asthma subgroups Matthew Gueble (Durham, United States of America), Matthew Gueble, Carole Holm, Nicole Grant, Lois Ravage-Mass, Terri-Dawn Levesh, Jean Estrom, Eleni Kapagiannidou, Qing Liu, Peggy O’Connor, Jose Gomez-Villalobos, Lauren Cohn, Geoffrey Chupp
Exacerbations in the subpopulations and intermediate outcome measures in COPD study (SPIROMICS, NHLBI) are associated with sputum eosinophilia but not blood eosinophilia Annette Hastie (Winston-Salem, United States of America), Annette Hastie, Fernando Martinez, Jeff Curtis, Claire Doerschuk, Nadia Hansel, Stephanie Christenson, Nirupama Putcha, Victor Ortega, R. Graham Barr, Betsy Carretta, David Couper, Eric Hoffman, Richard Kanner, Eric Kleerup, Neil Alexis, Prescott Woodruff, MeiLan Han, Deborah Meyers, Eugene Bleecker
Triggering receptor expressed on myeloid cells (TREM1): A novel biomarker in the investigation of non-CF bronchiectasis? Preliminary results Katerina Antoniou (Heraklion, Crete, Greece), Athanasia Proklou, Giorgos Pitsidianakis, Eliza Tsitoura, Chara Koutoulaki, Argyro Hatziantoniou, Despoina Moraitaki, Dimitrios Georgopoulos, Katerina Antoniou, Nikos Tzanakis
Determinants of oxidants load in broncho-alveiolar milieu Giuseppe Valerio (Brindisi, Italy), Giuseppe Valerio, Pierluigi Bracciale, Donato Lacedonia
Inflammatory-cellular composition of the induced sputum (IS) and activity of leucocytes myeloperoxidase (MPO) in asthmatics with different airway response to hyperosmolar stimulus Juliy M. Perelman (Blagoveshchensk, Russian Federation), Juliy Perelman, Aleksey Pirogov, Anna Prikhodko, Sergey Zinoviev, Evgeniya Afanaseva, Victor Kolosov
Proteome fingerprints define groups with distinct clinico-pathological phenotypes in the U-BIOPRED asthma study James Schofield (Southampton, United Kingdom), James Schofield, Dominic Burg, Doroteya Staykova, Julie Corfield, Ian Adcock, Kian Fan Chung, Peter Sterk, Paul Skipp, Ratko Djukanovic
A novel flow cytometric based method to measure kinase inhibition in sputum from COPD subjects Grant Nicholson (London, United Kingdom), Grant Nicholson, Rebecca Holloway, Brian Leaker, Iain Kilty, Mikhail Salganik, Peter Barnes, Louise Donnelly
IL-17A is elevated in patients with COPD and contributes to airway remodeling by acting on fibroblasts Tianwen Lai (Hangzhou, China), Tianwen Lai, Baoping Tian, Chao Cao, Luangqing Che, Yue Hu, Feng Xu, Songmin Ying, Wen Li, Zhihua Chen, Huahao Shen