Radiosensitisation of lung cancer by Z-VAD, a pan-caspase inhibitor: upregulation of autophagy and inhibition of cell proliferation

L. Moretti, K. W. Kim, K. Niermann, B. Lu (Nashville, United States Of America)

Source: Annual Congress 2009 - Basic science and lung cancer
Session: Basic science and lung cancer
Session type: Oral Presentation
Number: 3071
Disease area: Pulmonary vascular diseases, Thoracic oncology

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Moretti, K. W. Kim, K. Niermann, B. Lu (Nashville, United States Of America). Radiosensitisation of lung cancer by Z-VAD, a pan-caspase inhibitor: upregulation of autophagy and inhibition of cell proliferation. Eur Respir J 2009; 34: Suppl. 53, 3071

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Alpha1-antitrypsin inhibits staurosporine-induced apoptosis of NSCLC cells
Source: Virtual Congress 2020 – Biological mechanisms of lung cancer
Year: 2020


The inhibition of fas-mediated apoptosis of lung alveolar epithelial cells by cyclin dependent kinase inhibitor p21
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

Induction of apoptosis in murine alveolar epithelial cells by a proteasome inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

Blocking VEGF does not induce proapoptotic effects in the NSCLC cell line A549
Source: Annual Congress 2010 - New insights in the pathology of lung cancer
Year: 2010


Magnolol can induce apoptosis in non-small cell lung cancer via caspase-independent pathway
Source: Annual Congress 2011 - Biomarkers and other new methods for lung cancer
Year: 2011

Involvement of proteasome inhibition and p53 accumulation in epithelial apoptosis of lung injury
Source: Eur Respir J 2005; 26: Suppl. 49, 101s
Year: 2005

GSK-3 inhibition suppresses lung cancer cell survival, metastasis and proliferation through down-regulation the phosphorylation sites of CAP1
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

Proteasome inhibitors modulate chemokine production in lung epithelial and monocytic cells
Source: Eur Respir J 2004; 24: 40-48
Year: 2004



TRAIL and Bax-mediated apoptosis, pathways by which apoptosis may be induced in emphysema
Source: Eur Respir J 2006; 28: Suppl. 50, 824s
Year: 2006

Targeting of endothelial progenitor cells with the proteasome inhibitor bortezomib
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


Caspase recruitment domain containing protein 9 suppresses non-small cell lung cancer proliferation and invasion via inhibiting MAPK/p38 pathway
Source: Virtual Congress 2020 – Molecular alterations and immunology in lung cancer
Year: 2020

The inhibitory effect of PI3k inhibitor and MEK inhibitor on malignant pleural mesothelioma cell growth
Source: Annual Congress 2009 - Pleural and mediastinal diseases
Year: 2009


Triptolide enhances radiosensitivity of lung cancer cells via G2/M arrest and autophage
Source: Virtual Congress 2020 – Biological mechanisms of lung cancer
Year: 2020


ONX0912, a novel proteasome inhibitor for the treatment of lung fibrosis?
Source: Annual Congress 2012 - New drug targets and pre-clinical models for respiratory diseases
Year: 2012

Bcl-2 overexpression inhibits apoptotic cell death, but is not sufficient to protect L929 cells from hyperoxia
Source: Eur Respir J 2005; 26: Suppl. 49, 345s
Year: 2005

SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Source: International Congress 2016 – Basic science and case reports in lung cancer
Year: 2016

Targeting of STAT3 and survivin with TG101209, a novel JAK2 inhibitor, enhances radiotherapy in lung cancer models
Source: Annual Congress 2010 - New insights in the pathology of lung cancer
Year: 2010

Functional expressions of EGFP/LKB1 and its kinase domain induced apoptosis and enhanced chemosensitivity in lung cancer cell lines
Source: Eur Respir J 2004; 24: Suppl. 48, 5s
Year: 2004

Effect of PDE4 inhibitors on MAPK activation and IL-8 production on A549 cells following the induction of oxidative stress
Source: Eur Respir J 2005; 26: Suppl. 49, 99s
Year: 2005