Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Disease area: Airway diseases

Abstract

Cytokine networks are important in various inflammatory and infectious lung conditions, though their exact role and their functional interrelationships remain largely unknown. High concentration of various cytokines occur in sputum and bronchoalveolar lavage from patients with CF. It has been argued that this compartment may better reflect the local inflammatory response in the lung than circulating mediators.
The aim of the study was to analyze circulating concentration of interleukin 6 (IL 6) as a proinflammatory and interleukin 10 (IL-10) as anti-inflammatory cytokine in cystic fibrosis patients in different phase of the disease.
Methods: The group of 30 CF patients, mean age 23.7 yrs (18 females and 12 males) and 10 healthy control (HC) subjects was studied. Patients were grouped according to the phase of the bronchopulmonary disease. Symptoms and signs suggested the exacerbation in the course of the disease was used to single out the groups: E – patients with exacerbation (n=14); S – stable phase of the disease (n=16).
Serum IL 6 and IL 10 concentration was measured using a specific sandwich ELISA.
Results:
1. Serum IL 6 concentration was higher in group E versus S (p = 0.01), and E versus HC (p=0.007). There was no difference between serum IL 6 concentration between group S and HC (p=0.79).
2. In contrast, the serum level of IL 10 in group E was significantly lower than in HC (p = 0.01), but no statistical difference was revealed between group E versus S and S versus HC.
Conclusion: Increased circulating IL 6 and decreased IL 10 concentration could also be considered as indicating the acute exacerbation in the course of CF.

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Citations should be made in the following way:
J. Gozdzik, A. Nowicka, S. Cofta, T. Piorunek (Poznan, Poland). Circulating inflammatory cytokines in adult cystic fibrosis patients. Eur Respir J 2009; 34: Suppl. 53, 1257

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