Source: Annual Congress 2009 - Treatment of lung cancer
Disease area: Thoracic oncology

Abstract

Background: Chemotherapy is the cornerstone of the treatment of metastatic lung cancer. Betatubulin 3 is a component of the microtubules involved during cell proliferation. It is a target for some drugs of chemotherapy like taxanes and vinca-alcaloïdes. Over-expression of betatubulin 3 could be associated with resistance to those drugs. Little is known about the biology of this protein. In particular there is no data about the conservation of its expression during the metastatic process.
Aims and objectives : The aim of this study was to determinate if expression of betatubulin 3 is correlate between primary non small cells lung cancer (NSCLC) tumors and matched metastasis.
Methods : Twenty-eight patients with metastatic NSCLC were included. Primary tumor and metastases were operated or biopsied for each patient. The expression of Betatubulin 3 in each tumor was evaluated with immunohistochemistry.
Results : Betatubulin 3 was over-expressed in 12 (48%) primary tumors and 16 (57%) metastases. Expression of Betatubulin 3 was discordant between primary tumors and metastases in 5 (20%) pairs of tumors. Expression of Betatubulin 3 is correlated (Spearman‘s correlation coefficient = 0.62, p < 0.001) and concordant (Kendall‘s tau B test = 0.62, p < 0.001) between primary tumor and metastases in NSCLC.
Conclusions : Betatubulin 3 expression is correlated between primary tumor and metastases in NSCLC. It is not necessary to evaluate every site of the disease for this marker before discussing a treatment with taxanes or vinca-alcaloïdes.

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Citations should be made in the following way:
J. B. Roseau, A. M. Taseï, V. Pradel, D. Figarella-Branger, P. Astoul (Toulon, Marseille, France). Does expression of betatubulin 3 correlate between primary non small cells lung cancer tumor and metastases?. Eur Respir J 2009; 34: Suppl. 53, 2657

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