The role of cardio pulmonary exercise testing (CPET) in patients with cystic fibrosis (CF)
M. Damin, A. Borruso, L. Menin, B. M. Assael, U. Pradal (Padova, Verona, Italy)
Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Session: Cystic fibrosis: advances in clinical research
Session type: Thematic Poster Session
Number: 1267
Disease area: Airway diseases
Abstract Pulmonary function is the most important prognostic factor in CF. A reduced exercise capacity has a negative impact on prognosis as well. However the role of CPET is still to be determined in clinical practice. We studied 152 patients with CF (80 M 16-48 yrs and 72 F 13-46 yrs) who performed an incremental exercise test on a cycle ergometer. Patients were divided in three groups according to the degree of airway obstruction, i.e. mild (FEV1>60%pred, Group A), moderate (FEV1 40-60%pred, Group B) and severe (FEV1<40%pred, Group C). Measurements included lung function testing, nutritional status (BMI) and CPET parameters. Exercise capacity, in terms of maximum workload (Wmax%pred) and peak oxygen consumption (VO2%pred), was strongly related to FEV1%pred (r=0.909, p<0.0001 for Wmax, r=0.752, p<0.0001 for VO2) and, to a lesser extent, to BMI (r=0.399,p<0.001 for VO2). No gender related difference was found. Mean Wmax%pred. was 89 in Group A, 75 in group B and 55 in Group C. Interestingly in Group B some patients showed Wmax values lower than 55%pred, usually considered to be related to a poorer prognosis. Statistically significant differences were also found among groups for VO2%pred, minute ventilation, ventilatory reserve, and O2 pulse at the exercise‘s peak. In conclusion: in CF exercise capacity is limited mainly by respiratory impairment. In mild patients CPET can be useful to plan a personal training, in severe patients to assess a comprehensive strategy to prevent general physical deterioration (in view of a possible lung transplantation), and in moderate patients to identify those with a poorer prognosis who could benefit from a closer follow-up and treatment strategy.
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M. Damin, A. Borruso, L. Menin, B. M. Assael, U. Pradal (Padova, Verona, Italy). The role of cardio pulmonary exercise testing (CPET) in patients with cystic fibrosis (CF). Eur Respir J 2009; 34: Suppl. 53, 1267
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