Effectiveness of photodynamic therapy (PDT) in lung cancer treatment
S. V. Orlov, V. A. Gerasin, A. B. Butenko, A. V. Derevyanko, L. V. Stelmach, M. A. Urtenova (Saint-Petersburg, Russian Federation)
Source: Annual Congress 2009 - Treatment of lung cancer
Session: Treatment of lung cancer
Session type: Thematic Poster Session
Number: 2651
Disease area: Thoracic oncology
Abstract Objective: study of efficiency of a photodynamic therapy (PDT) at various stages of lung cancer.Methods: 20 patients, aged 44-77, were examined. Most patients (n=16; 80%) had III or IV stage of lung cancer, 4 patients (20%) had lung cancer in early stage (ca in situ, I stage). PDT was made during bronchofiberscopy under local anesthesia. Patients were intravenously injected with photogem® (2mg/kg body weight) and 24 – 48 hours later they received PDT with illumination light generated by gold vapor laser (630 nm, 200 j/sm-1 ). 7 patients (35%) previously had NdYAG laser debulking treatment under rigid bronchoscopy with general anesthesia. Other kinds of treatment (polychemotherapy, radiotherapy) were used for all patients in a various combinations.Results: After PDT in patients with late stages of lung cancer full excision of an endobronchial part of a tumor was observed in 5 of 16 patients, including one patient with resolved a lung atelectasis. Appreciable decrease of endobronchial obstruction due to reduction of a tumor mass has been noted in 6 patients. In 5 cases PDT was not effective. In all patients with early stage of lung cancer has been reached a full excision of a tumor as a result of a PDT application. In 2 cases big size tumor of a trachea (diameter more then 1,5sm) was totally removed with used to bronchoscopic electroexcission, a laser photodestruction and PDT. It is no recurrent tumor within 2-4 years after treatment.Conclusion: thus, using PDT in combination with other methods increase efficiency of a lung cancer treatment both in early and in late stages of disease.
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S. V. Orlov, V. A. Gerasin, A. B. Butenko, A. V. Derevyanko, L. V. Stelmach, M. A. Urtenova (Saint-Petersburg, Russian Federation). Effectiveness of photodynamic therapy (PDT) in lung cancer treatment. Eur Respir J 2009; 34: Suppl. 53, 2651
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