The heat shock protein 90 inhibitor, 17-AAG, ameliorates pulmonary arteriolar and right ventricular hypertrophy in monocrotaline-induced pulmonary arterial hypertension

C. Dimitropoulou, M. L. Meadows, C. Snead, S. A. Barman, J. D. Catravas (Augusta, United States Of America)

Source: Annual Congress 2009 - Pulmonary circulation II
Session: Pulmonary circulation II
Session type: Thematic Poster Session
Number: 3936
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Dimitropoulou, M. L. Meadows, C. Snead, S. A. Barman, J. D. Catravas (Augusta, United States Of America). The heat shock protein 90 inhibitor, 17-AAG, ameliorates pulmonary arteriolar and right ventricular hypertrophy in monocrotaline-induced pulmonary arterial hypertension. Eur Respir J 2009; 34: Suppl. 53, 3936

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Bosentan combined with sildenafil prevents right ventricular hypoxia in pulmonary arterial hypertension
Source: Annual Congress 2008 - Pathophysiology of pulmonary hypertension
Year: 2008


Urocortin-2 improves right ventricular function and attenuates experimental pulmonary arterial hypertension
Source: International Congress 2018 – Pulmonary hypertension: therapy
Year: 2018


Effect of sitaxentan on haemodynamics and right ventricular hypertrophy in monocrotaline-induced pulmonary arterial hypertension (PAH)
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008


Lodenafil improves hemodynamics and right ventricular remodeling in monocrotaline-induced model of pulmonary arterial hypertension in rats
Source: Annual Congress 2010 - Experimental pulmonary hypertension
Year: 2010

Improvement of exercise capacity in monocrotaline induced pulmonary hypertension by the phosphodiesterase inhibitor Vardenafil
Source: Annual Congress 2006 - Signalisation in the pulmonary vasculature: new pathways and wrong signals
Year: 2006


Carvedilol partially reverses maladaptive remodeling and improves function of the right ventricle (RV) in experimentally-induced pulmonary arterial hypertension (PAH)
Source: Annual Congress 2009 - Pathobiology of pulmonary vascular diseases
Year: 2009


Increased right ventricular cardiomyocyte stiffness in patients with pulmonary arterial hypertension
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and cell biology
Year: 2012

How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension
Source: Eur Respir J, 50 (2) 1700764; 10.1183/13993003.00764-2017
Year: 2017



Combining bosentan and sildenafil improves mitochondrial capacity and restores right ventricular contractility in established pulmonary hypertension
Source: Annual Congress 2007 - Pathogenesis and novel therapeutic targets in pulmonary hypertension
Year: 2007


Prevention and partial reversal of monocrotaline-induced pulmonary arterial hypertension (PAH) by hsp90 inhibitors
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

2-Ethoxyestradiol inhibits vascular and cardiac remodeling and attenuates monocrotaline-induced pulmonary hypertension
Source: Annual Congress 2007 - Cellular and molecular aspects of pulmonary hypertension
Year: 2007


Right ventricular and pulmonary vascular interaction in pulmonary arterial hypertension
Source: Annual Congress 2008 - Pulmonary hypertension in connective tissue diseases
Year: 2008


Cystamine and sildenafil in treatment of right ventricular hypertrophy in rats with pulmonary hypertension
Source: Annual Congress 2008 - Pulmonary hypertension II
Year: 2008


HDAC inhibitor quisinostat reduces pulmonary vascular remodeling in experimentally induced pulmonary arterial hypertension
Source: Virtual Congress 2020 – Pathophysiology of pulmonary hypertension
Year: 2020


Amelioration of right ventricular morphology and systolic function in patients with severe group 3 pulmonary hypertension treated with pulmonary vasodilators
Source: International Congress 2015 – Pulmonary hypertension in lung disease
Year: 2015


ACE2 activation improves pulmonary endothelial function and attenuates monocrotaline-induced pulmonary hypertension
Source: Annual Congress 2011 - Treatment of human pulmonary hypertension
Year: 2011


Vascular and right ventricular remodelling in chronic thromboembolic pulmonary hypertension
Source: Eur Respir J 2013; 41: 224-232
Year: 2013



2-Methoxyestrone inhibits vascular remodeling and attenuates monocrotaline-induced pulmonary hypertension
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008

In a model of genetic pulmonary hypertension, VIP attenuates pulmonary vascular remodeling and right ventricular hypertrophy
Source: Annual Congress 2007 - Pathogenesis and novel therapeutic targets in pulmonary hypertension
Year: 2007