Source: Annual Congress 2009 - Socio-economic and epidemiological aspects of sleep apnoea
Disease area: Sleep and breathing disorders

Abstract

BACKGROUND: There is a large body of research evidence suggesting a male predominance in cardiovascular mortality rates. In this context, we aimed to address the impact of gender in a consecutive middle-aged sleep clinic cohort. MATERIAL: All participants (n=1323; 1013 men, 310 women; mean age 49.5± 9.7, range 30-69 yrs) were free of any cardiac or pulmonary disease, diabetes, malignancy, psychiatric disorder or alcohol dependency at the time of the sleep recordings (January 1993 to December 1995). OSA (Oxygen Desaturation Index ≥5/h) was observed in 38.5 % of men and 24.8 % of women (p<0.001). Efficiently treated OSA patients (n=75) during the 7-yr follow-up were excluded from the final analysis. RESULTS: In the remaining cohort, both overall and cardiovascular mortality rates were higher in OSA patients compared to in non-OSA (4.7% vs 2.6%; p=0.05 and 3.5% vs 0.4%; p<0.001, respectively). In a multivariate analysis, overall mortality was predicted by age whereas cardiovascular mortality by OSA (odds ratio [OR] 7.1, 95% confidence interval [CI] 2.0-25.5) adjusted for age and BMI in the whole cohort. With regard to gender, OSA predicted cardiovascular mortality with ORs of 8.3 in men and 11.3 in women (95% CIs 1.7-40.1 and 1.2-105.8, respectively). CONCLUSION: Our data suggest a markedly increased risk of cardiovascular mortality both in men and women with OSA. In this middle-aged sleep clinic cohort, the contribution of OSA to cardiovascular mortality was not gender-dependent.
Supported by the Swedish Heart-Lung-Foundation, Carnegie Foundation and ALF grants from West Goetaland Region. YTC is the recipient of a European Respiratory Society / European Lung Foundation Fellowship (Number 156).

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Y. Peker, S. Thorvaldsson, Y. Turgut Celen, E. Thunström, L. Grote, J. Hedner (Skoevde, Gothenburg, Sweden). Is there a gender difference in cardiovascular mortality in obstructive sleep apnoea?. Eur Respir J 2009; 34: Suppl. 53, 3672

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