Indacaterol dose selection: utilising an adaptive seamless design in a clinical study in COPD

P. J. Barnes, S. J. Pocock, H. Magnussen, A. Iqbal, B. Kramer, M. Higgins, D. Lawrence (London, West Sussex, United Kingdom; Grosshansdorf, Germany; East Hanover, United States Of America)

Source: Annual Congress 2009 - Next generation bronchodilators
Session: Next generation bronchodilators
Session type: E-Communication Session
Number: 4358
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. J. Barnes, S. J. Pocock, H. Magnussen, A. Iqbal, B. Kramer, M. Higgins, D. Lawrence (London, West Sussex, United Kingdom; Grosshansdorf, Germany; East Hanover, United States Of America). Indacaterol dose selection: utilising an adaptive seamless design in a clinical study in COPD. Eur Respir J 2009; 34: Suppl. 53, 4358

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Clinical effectiveness of once-daily fluticasone furoate/umeclidinium/vilanterol in usual practice: the COPD INTREPID study design
Source: ERJ Open Res, 5 (4) 00061-2019; 10.1183/23120541.00061-2019
Year: 2019



A smart mHealth tool versus a paper action plan to support self-management of COPD exacerbations: a randomised controlled trial
Source: International Congress 2019 – M-health/e-health I
Year: 2019

A novel study design for the comparison between once-daily QVA149 and twice-daily salmeterol/fluticasone on the reduction of COPD exacerbations: The FLAME study
Source: Annual Congress 2013 –Asthma and COPD drugs: efficacy, safety and pharmacoeconomics
Year: 2013

Design and implementation of a multi-part, flexible protocol to assess the tolerability and pharmacodynamic effects of PUR118 in healthy subjects and COPD patients
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012


Adapting asthma clinical trials in response to the COVID-19 pandemic - the BenRex study design
Source: Virtual Congress 2021 – Severe asthma: evaluation using patient-reported outcome measures (PROMs) and biomarkers, comorbidities and treatments
Year: 2021


COPD and Seretide: a multi-centre intervention and characterisation (COSMIC) study: rationale and baseline characteristics
Source: Eur Respir J 2002; 20: Suppl. 38, 241s
Year: 2002

An electronic patient decision aid comparing as-needed budesonide-formoterol combination to regular use of inhaled corticosteroid (ICS) in mild asthma: a rapid-cycle design study
Source: Virtual Congress 2021 – Therapies for respiratory diseases in primary care and COVID - 19
Year: 2021


Effectiveness versus efficacy trials in COPD: how study design influences outcomes and applicability
Source: Eur Respir J, 51 (2) 1701531; 10.1183/13993003.01531-2017
Year: 2018



Efficacy of a comprehensive education program including inhaler training and COPD management during hospitalization of AECOPD, a randomized controlled clinical
Source: International Congress 2018 – Telehealth, home rehabilitation and specific adaptations to exercise interventions in different settings
Year: 2018




Effectiveness and acceptability of a smart inhaler asthma self-management programme: a cluster RCT study protocol
Source: International Congress 2019 – Innovations in primary care assessment and management
Year: 2019


Budesonide/formoterol adjustable maintenance dosing effectively improves asthma symptom severity: a multicentre Canadian study
Source: Eur Respir J 2003; 22: Suppl. 45, 258s
Year: 2003

Evaluation of data requirements to establish biologic quality control ranges in a multi-center clinical trial for inhaled insulin
Source: Annual Congress 2008 - New challenges and maintained quality: lung function for the future
Year: 2008


Initial inhaler choice in COPD: real-world evidence
Source: Breathe, 15 (4) 350; 10.1183/20734735.0256-2019
Year: 2019



Efficacy and safety of sequential three-step empirical therapy for chronic cough: a multi-center clinical study
Source: International Congress 2017 – Evolution or revolution in the treatment of asthma and allergies
Year: 2017

Effects of an internet based tool for self-management in patients with COPD–a controlled pragmatic pilot trial
Source: International Congress 2017 – The importance of physical activity in patients with COPD
Year: 2017



Safety profile of glycopyrronium in patients with COPD: An innovative approach to analyse data from post-marketing surveillance (PMS)
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


Comparison of an innovative multi-dose inhaler with the attributes of an 'ideal' inhaler: A multicentre randomised controlled trial (RCT)
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014

New clinical research strategies in thoracic oncology: clinical trial design, adaptive, basket and umbrella trials, new end-points and new evaluations of response
Source: Eur Respir Rev 2014; 23: 367-378
Year: 2014



The cost-effectiveness of early intervention with inhaled budesonide once daily: an international comparison of the results from the START study
Source: Eur Respir J 2002; 20: Suppl. 38, 43s
Year: 2002

Revising our approach to conducting therapeutic clinical research in COPD
Source: Eur Respir J, 51 (2) 1702712; 10.1183/13993003.02712-2017
Year: 2018