Source: Annual Congress 2009 - How to deal with tracheal stenosis
Disease area: Thoracic oncology

Abstract

Objective: To analyze the difference of baseline, clinical manifestations, response, and complications of Ultraflex Self-Expandable Metallic Stents (SEMSs) applied in patients with central airway obstruction.
Methods: From 2001 to 2006, 149 patients with benign (n=72) and malignant (n=77) airway disease received 211 SEMSs (116 benign lesions and 95 malignant lesions) were retrospectively reviewed in a tertiary hospital.
Results: Characters between patients with benign and malignant condition received SEMS implantation were significantly different, including age (63.9 + 15.6 years vs. 58 + 12.2 years; p=0.006), gender (male, 62.1% vs. 90.5%; p<0.0001), smoking (47.4% vs. 85.3%; p<0.0001) , forced expiratory volume in first one second (FEV1) (0.9 + 0.4L/s vs. 1.47 + 0.68L/s; p <0.0001), followed up days after SEMS implantation (median, IQR; 429 (141-856) vs. 57 (19-103); p<0.0001) and covered SEMS (36.2% vs. 94.7%; p<0.0001). Patients with benign condition had higher rate of symptoms resolution after SEMS implantation than that in patients with malignant condition.(76.7% vs. 51.6%; p<0.0001). The overall complication rate (42.2% vs. 21.1%; p=0.001) after SEMS implantation in patients with benign conditions were higher than those in patients with malignant conditions. Successful management rates of SEMS migration, granuloma formation and SEMS fracture were up to 100%, 81.25%, and 85% respectively.
Conclusions: Patients received SEMS implantation due to benign conditions had worse lung function and were older than those with malignancy. There was higher complication rate in patients with benign conditions especially granuloma formation and SEMS fracture than it in patients with malignancy.

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Citations should be made in the following way:
F. T. Chung, S. M. Lin, H. C. Chen, C. L. Chou, C. T. Yu, H. P. Kuo (Taipei, Taiwan). An outcome analysis of airway self-expandable metallic stent in central airway obstruction. Eur Respir J 2009; 34: Suppl. 53, 4238

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