Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research

Abstract

Background: Patients with cystic fibrosis (CF) marked reduced exercise capacity. As the submaximal exercise testing overcomes many of the limitations of maximal exercise testing, indexes of submaximal exercise capacity like time constant τon are of increased investigational interest.
Aim: To explore the correlation between time constant τon and breathing pattern parameters during maximal exercise testing in adult patients with CF.
Patients-Methods: 14 adult patients with CF (8males/6females, mean age 22) submitted to pulmonary functional tests during the baseline and maximal and submaximal CPET. We have calculated maximal respiratory rate (RRmax), tidal volume (Vt max), dead space to tidal volume ratio (Vd/Vt), maximal inspiratory time (Ti max), VT / Ti max, Ti / Ttot max, breathing reserve (BR), O2pulse, maximal inspiratory capacity (ICmax).
Results: A statistically significant negative correlation is found between τon and Vt (r=-0,557, p<0,003), BR (r=-0,743, p<0,002), O2pulse (r=-0,544, p<0,044) and Ti max (r=-0,625, p<0,017). Also, a statistically significant correlation is found between τon and RR (r= 0,539, p<0,046) and Vd/Vt max (r= 0,739, p<0,003). Contrariwise there is no correlation between τon and VT / Ti max (r = -0,354 and p < 0,215) neither between τon and Ti / Ttot max (r = -0,355 and p<0,212).
Conclusion: There is a correlation between maximal exercise parameters and submaximal oxygen kinetics in adult patients with cystic fibrosis. Further investigation of this finding is needed.

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E. Armeniakou, G. Perpati, M. Avdikou, C. Pappas, E. Stefanatou, T. Soulele, V. Nanou, P. Roditis, E. Pouliou, S. Nanas (Athens, Greece). Oxygen kinetics during submaximal cardiopulmonary exercise testing (CPET) in adult patients with cystic fibrosis is related to maximal exercise breathing pattern. Eur Respir J 2009; 34: Suppl. 53, 1261

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