Source: Annual Congress 2009 - Socio-economic and epidemiological aspects of sleep apnoea
Disease area: Sleep and breathing disorders

Abstract

Hypothyroidism is a risk factor for obstructive sleep apnoea (previous data has shown high incidence of OSA among hypothyroid patients). The aim of this study was to assess prevalence of hypothyroidism in OSA subjects and influence of this disorder on OSA severity. We studied 680 OSA pts (513 males and 167 females), mean age - 55.9±10.3 years with moderate and severe disease (AHI – 37.6±21.8) and obesity (BMI = 34.4±6.7). Hypothyroidism (elevated plasma concentration of TSH) was found in 18 pts (2.6%). Comparison of OSA subjects with- and without hypothyroidism is shown in the table.

Variable	OSA (N = 662)	OSA and hypothyroidism (N=18)	p
Age (years)	56±10.2	52±13.5	NS
AHI (n/h)	37.5±21.7	40.9±22.8	NS
T 90 (%)	29.4±26.3	33.1±29.9	NS
BMI (kg/m2)	34.5±6.7	33.4±6	NS
Epworth Sleepiness Score (points)	11.7±5.7	13.6±3.8	NS
Coronary artery disease (n/% of pts)	160 (24.2%)	7 (38.9%)	NS
Heart failure (n/% of pts)	89 (13.4%)	1 (5.6%)	NS
Arterial hypertension (n/% of pts)	488 (73.7%)	9 (50%)	p=0.025
Hypertriglicerydaemia (n/% of pts)	282 (42.7%)	11 (61.1%)	NS
Hypercholesterolaemia (n/% of pts)	302 (45.7%)	11 (61.1%)	NS
Mixed Hyperlipidaemia (n/% of pts)	179 (27.1%)	9 (50%)	p=0.03

Conclusions: Incidence of hypothyroidism in OSA subjects was low. OSA severity, BMI and prevalence of cardiovascular diseases were not higher in subjects with concomitant hypothyroidism.

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Citations should be made in the following way:
R. Plywaczewski, B. Kazanecka, L. Jonczak, D. Gorecka, P. Sliwinski (Warsaw, Poland). Obstructive sleep apnoea (OSA) and hypothyroidism. Eur Respir J 2009; 34: Suppl. 53, 3679

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