Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Disease area: Sleep and breathing disorders

Abstract

Objective:Our aim was to assess the efficacy of NIV during chest physiotherapy for the treatment of patients with cystic fibrosis.
Design:7 patients of mean(SD) age 25,2(4,7) years and forced expiratory volume in 1 second (FEV1) 42,1 (4,7)% predicted completed a randomised crossover trial receiving 5 week of (1) standard treatment (active cycle of breathing technique, ACBT), (2) ACBT plus oxygen therapy, (3) ACBT plus NIV.Data were collected at baseline and at the end of each treatment period.
We recorded arterial blood gas,spirometric parameters,peak exercise capacity by shuttle walking test (SWT), sleep parameters as the sleep Apnea/Hypopnea Index (AHI), the mean SaO₂%( %TST), oxygen desaturation index (ODI),SaO₂ <90%( %TST),tcPCO2mean of TST (transcutaneous carbon dioxide tension).
Results:Comparing ACBT-oxygen group and ACBT group we found significant improvement for sleep parameters as AHI (p= 0.00),ODI (p=0.00),SaO₂ mean% (p=0.00), SaO₂ < 90% (p=0.00) but caused a rise in tcPCO2 mean(p=0.00).Non significant differences were found comparing the other parameters.Comparing ACBT-NIV group and ACBT group had a significant effect on sleep parameters as AHI (p= 0.00),ODI (p=0.00),SaO₂ mean% (p=0.00),SaO₂ < 90% (p=0.00) and significant reduction TcPCO2 mean (p=0.00); NIV plus ACBT produced a increase in shuttle distance also (SWT, P=0.00).Non significant differences were found comparing the other parameters
Conclusions:Although these preliminary data need to be confirmed by larger study,
NIV plus ACBT improve both Sleep Disorder Breathing and exercise performance.We have shown that NIV during chest Phisiotherapy can safely be essential to the management of cystic fibrosis.

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Citations should be made in the following way:
A. Petrone, M. Quartieri, A. Tolisano, C. Tirone, F. Tirone (Lungro, Rome, Italy). Non invasive ventilation (NIV) assists chest physiotherapy for treatment of patients with cystic fibrosis. Eur Respir J 2009; 34: Suppl. 53, 1262

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