Source: Annual Congress 2009 - How to deal with tracheal stenosis
Disease area: Respiratory infections

Abstract

OBJECTIVE: Airway stenting is increasingly used in the management of obstructive lesions of the central airway. Microbiological colonization of the airway stents causes therapy resistant halitosis and severe airway infections. We coated clinically applied tracheal stents with a thin layer of silver nano-particles to prevent bacterial colonization in vitro.
METHODS: Tecoflex^® Polyurethane sheets (n=5) were coated with silver nano-particles by immersion in a colloidal silver solution, generated from silver nitrate by reduction with sodium citrate in distilled water, for 2 hours and exposed to a hydrogen plasma glow discharge for silver colloid fixation. To test for bacterial colonization, stent materials were incubated for 1-3 days in vitro with i) Micrococcus luteus (ML), ii) E. coli (EC) and iii) Pseudomonas aeruginosa (PA). Antimicrobial activity was evaluated by bacterial growth inhibition. Stent surface colonization was investigated by raster electron microscopy.
RESULTS: The covering procedure resulted in an 80 nm silver nano-coating. It shows antibacterial activity against gram-positive (ML) and gram-negative (EC) bacterial strains, especially PA, by inhibiting bacterial stent surface seeding. Additionally, the coating exerts its antibacterial activity on the stent environment, suppressing colony formation.
CONCLUSIONS: Nano-silver coating using plasma technology may increase the biocompatibility of tracheal stents in clinical applications, thereby eliminating the cause for halitosis and airway infections.

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Citations should be made in the following way:
T. Walles, H. Mertsching, I. Trick, M. Müller, C. Oehr (Gerlingen, Stuttgart, Germany). Surface modification of tracheal stents by silver nano-particles to prevent bacterial colonization. Eur Respir J 2009; 34: Suppl. 53, 4240

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