Source: Annual Congress 2009 - Prognosis and comorbidities in COPD
Disease area: Airway diseases

Abstract

Background: Little is known about the 6MWD in women with COPD.
Objective: Determine the 6MWD of women with COPD from 3 different continents.
Patients and Methods: 6MWD was performed in COPD patients from 5 countries (Boston, Tampa, Venezuela, Chile, Uruguay, Tenerife, Pamplona and Zaragoza). We registered age, BMI, pack years history, comorbidities, disnea (MRC) and FEV1, FVC, FEV1/FVC in all patients and in those with COPD IC and IC/TLC. We calculated % of predicted values and performed a linear regression analysis to determine which parameters predict 6MWD.
Results: 206 normals (42 USA, 68 Spain, 96 South America) and 223 COPD women (71 USA, 60 Spain, 92 South America) participated in the study. COPD women have 63± 10 years, 40% were current smokers with a 51± 29 packs-yrs history, have a Charlson index of 2.7± 2.4 and a FEV1% 50± 19. Normal women walked 551± 80m. Women with COPD walked less (402± 78m, 73% of normal) in all continents (USA 329± 110, 61%; Spain 464± 83, 84%; South America 414± 78, 73%). 6MWD decreased by GOLD stages (Figure). Factors that predict 6MWD were MRC, FEV1, age, IMC, Charlson index and smoking status.
Conclusions: 6MWD is decreased in women with COPD, showing regional differences. The distance walked decreased from GOLD stage II. Pulmonary and extra-pulmonary factors predict the 6MWD in women with COPD.

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J. P. De Torres, C. Casanova, C. Cote, O. Díaz, M. V. López, V. Pinto-Plata, J. M Marín, B. R. Celli (Pamplona, Sabnte Cruz de Tenerife, Zaragoza, Spain; St Petersburg, Boston, United States Of America; Santiago, Chile; Montevideo, Uruguay). Six-minute walking distance in women with COPD. Eur Respir J 2009; 34: Suppl. 53, 517

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