Screening of sleep apnea-induced hypertension and acute effect of continuous positive airway pressure
V. Donic, S. Grešová, Z. Tomori, I. Peregrím (Košice, Slovakia)
Source: Annual Congress 2009 - Socio-economic and epidemiological aspects of sleep apnoea
Session: Socio-economic and epidemiological aspects of sleep apnoea
Session type: Thematic Poster Session
Number: 3682
Disease area: Sleep and breathing disorders
Abstract Background: Sleep apnea/hypopnea syndrome (SAHS) characterized by severe breathing disorders and hypoxemia during sleep often result in arterial hypertension (AH), frequently remaining undiagnosed. Methods: Thirty blood pressure (BP) and polysomnographic parameters were measured in 116 adult males using a polysomnograph Alice 3, Respironics and a BP monitor CardioTens, Meditech, to test their usefulness for screening of both SAHS and AH. Results: Compared to clinically healthy controls and patients with essential AH, SAHS manifested by increased apnea/hypopnea index, apnea index, duration of arterial oxygen saturation below 85%, and decrease of average arterial oxygen saturation, correlating with nocturnal average diastolic BP (p=0.0049, p=0.0027, p=0.049 and p=0.0457, respectively). The acute antihypertensive effect of various types of continuous positive airway pressure (CPAP) therapy of SAHS significantly reduced the apnea/hypopnea episodes and the secondary component of AH caused by excessive sympathetic stimulation. For the SAHS-induced, dose-dependent, CPAP-responsive component of AH, the following parameters with decreasing significance proved to be useful: nocturnal average systolic and diastolic BPs, 24-h average systolic and diastolic BPs, as well as Percent Time Elevation and Mean Pressure Load. Conclusion : BP monitoring proved to contribute to early diagnostic, prognostic stratification of cardiovascular, neuro-muscular, endocrine-metabolic and other complications and adequate CPAP therapy of secondary component of AH caused by SAHS.
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V. Donic, S. Grešová, Z. Tomori, I. Peregrím (Košice, Slovakia). Screening of sleep apnea-induced hypertension and acute effect of continuous positive airway pressure. Eur Respir J 2009; 34: Suppl. 53, 3682
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