Source: Annual Congress 2009 - Prognosis and comorbidities in COPD
Disease area: Airway diseases, Sleep and breathing disorders

Abstract

Objective. To assess prevalence of systemic (extrapulmonary) effects in patients with chronic obstructive pulmonary disease (COPD) and their relation to disease severity.
Methods. We performed a cross-sectional study including 84 COPD patients (Stage II-IV), 54 male and 30 female, mean age 62.4±12.3 yrs, mean duration of the disease 12.3±7.2 yrs, mean FEV₁ 64.4±20.7%. Systemic effects (weight loss, exercise intolerance, anemia, sleep-disordered breathing, and depression) were assessed by completion of a questionnaire, body mass index calculation, 2-min walk test, blood analysis, and psychological evaluation.
Results. Prevalence of overall systemic effects in examined subjects was 76.2% with highest frequency of exercise intolerance (72.6%) and weight loss (64.2%), and lowest one for anemia (36.9%). We found higher prevalence of systemic effects in the subjects whose disease lasted more then 12 yrs than in the subjects with shorter duration of the disease (71.4% vs. 47.7%) but statistical significance was not reached. Prevalence of systemic effects was significantly higher in the subjects with very severe COPD and severe COPD than in the subjects with moderate COPD (100% vs. 44.8%, P < 0.05, both).Conclusion. Our findings support the close relation between disease severity and occurrence of systemic effects in the subjects with COPD.

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Citations should be made in the following way:
Z. Stojanovski, J. Minov, S. Ivanov (Skopje, Kumanovo, Fyrom). Systemic effects in patients with chronic obstructive pulmonary disease: a role of disease duration and disease severity. Eur Respir J 2009; 34: Suppl. 53, 516

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