Acute effects of noninvasive ventilation during incremental exercise test in chronic obstructive pulmonary disease patients
I. M. Oliveira, R. R. Britto, R. A. Borges, T. A. Oliveira, V. F. Parreira (Belo Horizonte, Betim, Brazil)
Source: Annual Congress 2006 - Training strategies and education in rehabilitation
Session: Training strategies and education in rehabilitation
Session type: Poster Discussion
Number: 3189
Disease area: Airway diseases, Respiratory critical care
Abstract This study evaluated the direct effects of noninvasive ventilatory support (NIVS) on cardiopulmonary and metabolic response during exercise in patients with chronic obstructive pulmonary disease (COPD). Seventeen patients (68,177±6,40 yrs) performed two incremental exercise test (IT) one without (control) and another with NIVS (Bilevel). Lactate level (LL), mean arterial pressure (MAP), dyspnea score, heart rate (HR) and transcutaneous oxygen saturation (SpO2 ) were evaluated in both tests. The anaerobic threshold (AT) was calculated from semiparametric mathematical modeling based on heart rate variability. We compared outcomes on resting, anaerobic threshold (AT) and peak exercise. In the control trial the LL at peak exercise compared to rest increased significantly (4,68±1,05 vs 3,55±0,92 mmol/L; p < 0,05), the peak lactate level were significantly higher than Bilevel trial (4,68±1,05 vs 4,01±1,14 mmol/L; p < 0,05) and the SpO2 presented a significant fall at AT and peak exercise compared to rest (90,81±4,57; 90,12±4,70 and 93,75±4,12% respectively, p<0,05). There were no differences in LL and in SpO2 during the test when Bilevel was applied. MAP and HR increased significantly during both trial as expected being physiologic response to exercise. Interestingly, exertional dyspnea was significantly higher at AT and peak exercise compared to rest (3,71±1,89 vs 5,12±1,16 and 1,05±1,13; p<0,05) in control trial, while with the use of NIVS only dyspnea at peak exercise was significantly different to rest (4,76±1,75 vs 0,70±0,90; p<0,05). Concluding, the use of NIVS during exercise kept constant level of lactate and SpO2 and alleviate exertional dyspnea.
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I. M. Oliveira, R. R. Britto, R. A. Borges, T. A. Oliveira, V. F. Parreira (Belo Horizonte, Betim, Brazil). Acute effects of noninvasive ventilation during incremental exercise test in chronic obstructive pulmonary disease patients. Eur Respir J 2006; 28: Suppl. 50, 3189
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