Source: Annual Congress 2006 - Training strategies and education in rehabilitation
Disease area: Airway diseases

Abstract

We conducted a randomised, placebo-controlled trial examining whether creatine supplementation enhances the benefits of pulmonary rehabilitation (PR), containing aerobic exercise and resistance training (RT).
Methods: 80 COPD subjects (GOLD stages I-IV) [mean(SD) age 68(7.8)yrs, FEV₁ 44.1(20.3)%predicted] completed 21 PR sessions, with enhanced RT, after baseline measurements and randomisation to creatine (Cr) or placebo (Pl) supplementation. A subgroup had muscle biopsies.
Results: Groups were well matched at baseline except for gender (M:F Cr 19:19, Pl 31:11, Chi² p = 0.03). Mean change in functional performance and muscle strength after PR are shown. Health status (CRQ-SR) improved significantly after PR but did not differ between groups. Muscle biopsies showed evidence of creatine uptake.
Conclusion: This adequately powered study showed significant improvements in all outcomes following PR. Creatine supplementation did not enhance these benefits.
Supported by British Lung Foundation.

	Within group change after PR		Between group
	Creatine (n=38)	Placebo (n=42)	mean difference
Weight (kg)	0.8 (0.2, 1.3)**	0.2 (-0.4, 0.8)	0.5 (-1.0, 1.3)
FFM	0.9 (0.1, 1.7)*	0.8 (-0.05, 1.6)	0.1 (-1.0, 1.3)
ISWT (meters)	84.0 (58.0, 109.9)**	83.8 (65.0, 102.6)**	0.1 (-30.9, 31.2)
ESWT (seconds)	377.4 (248.6, 506.3)**	487.4 (367.2, 607.6)**	-110 (-283.3, 63.3)
Isokinetic Quadriceps Strength (Nm)	19.2 (14.0, 24.3)**	19.5 (14.2, 24.7)**	-0.3 (-7.6, 7.0)
Isometric Quadriceps Strength (Nm)	19.6 (16.0, 23.3)**	23.1 (17.8, 28.4)**	-3.5 (-10.0, 3.0)

(95% CI), *p<0.05, **p<0.01

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S. J. Deacon, E. E. Vincent, S. J. Singh, M. C. Steiner, P. Greenhaff, M. D. Morgan (Leicester, Nottingham, United Kingdom). Does creatine supplementation enhance the effects of physical training during pulmonary rehabilitation in COPD?. Eur Respir J 2006; 28: Suppl. 50, 3188

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