Source: Annual Congress 2009 - Cystic fibrosis: advances in clinical research
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Aim. We evaluated the expiratory flow rate measuring with the bronchodilation test importance in the assessment of bronchial obstruction reversibility in children with chronic lung diseases.
Materials and methods. This study included 18 schoolchildren with bronchial asthma (BA) and 18 – with cystic fibrosis (FC). The diagnosis of the BA was established based on the GINA criterions. CF diagnosis has been made using a clinical features, sweat chloride test, identification of gene mutation. The expiratory flow rate measuring with the bronchodilation test permitted to assesses initial PEF1 and PEF2 in 20 minutes after salbutamol inhalation. The ΔPEF critical limit of 15% indicates the suggestive reversibility for the bronchial obstruction.
Results. The expiratory flow rate measuring denoted values of PEF1 191.1±14.1l/min, PEF2 267.5±26.3l/min in children with BA and of PEF1 239.4±28.9l/min (p>0.05), PEF2 267.2±31.1l/min (p>0.05) levels in children with CF. The ΔPEF index showed abnormal values of 24.1±2.3% in BA and 11.1±1.6% in CF with significant (p<0.001) increase in asthmatic children. An important reversibility of airflow obstruction was noted in children with BA; in this case obstruction is caused by bronchoconstriction. The obstruction reversibility was below the value of 15% in children with CF, were bronchial obstruction is due to viscous mucus hypersecretion and chronic bronchial inflammation.
Conclusion. The expiratory flow rate measuring with the bronchodilation test is an important tool in differential diagnosis of bronchial obstruction caused by bronchoconstriction in BA or by chronic bronchial inflammation with viscous mucus hypersecretion in CF.

Rating:

Share or cite this content

Citations should be made in the following way:
S. Sciuca, O. Turcu, R. Selevestru, E. Chioroglo (Chisinau, Republic Of Moldova). The importance of expiratory flow rate measuring in the differential diagnosis of chronic bronchial obstruction in children. Eur Respir J 2009; 34: Suppl. 53, 1251

Member's Comments

No comment yet.

Related content which might interest you: The significance of regular peak expiratory flow monitoring in severe childhood asthma Source: Eur Respir J 2005; 26: Suppl. 49, 165s Year: 2005 Forced expiratory tracheal noise time in diagnostics of hidden bronchial obstruction among spirometry negative asthma patients Source: Annual Congress 2011 - Lung function today and tomorrow I Year: 2011 Spirometry forced expiratory time is driven by central airway obstruction in asthmatic children Source: Virtual Congress 2021 – Best of paediatric physiology and sleep research Year: 2021 Exploring the clinical utility of measuring reversibility in mid expiratory flow and its relationship with FEV1 reversibility in patients with asthma. Source: International Congress 2017 – Biomarker-based asthma control Year: 2017 Diagnosis of initial mild airway obstruction in the patients with pulmonary tuberculosis by the forced oscillation technique Source: International Congress 2019 – Respiratory function assessment in disease Year: 2019 Diagnosis of a degree extrapulmonary airways stenosis by the analysis of the relation flow – volume - pressure at the quiet and forced breath Source: Eur Respir J 2003; 22: Suppl. 45, 358s Year: 2003 Increased prevalence of expiratory flow limitation during exercise in children with bronchopulmonary dysplasia Source: ERJ Open Res, 4 (4) 00048-2018; 10.1183/23120541.00048-2018 Year: 2018 Negative expiratory pressure method for detection of expiratory flow limitation in cystic fibrosis patients Source: Eur Respir J 2003; 22: Suppl. 45, 577s Year: 2003 Peak expiratory flow use for screening airflow obstruction and monitoring the bronchodilator effect in COPD patients in primary care settings Source: Eur Respir J 2006; 28: Suppl. 50, 738s Year: 2006 Comparison between peak expiratory flow rate (PEFR) and FEV1 in the monitoring of children suspected to asthma Source: Eur Respir J 2002; 20: Suppl. 38, 506s Year: 2002 Bronchial obstruction and reversibility in children: inspiratory or expiratory resistance? Source: Eur Respir J 2014; 44: 244-247 Year: 2014 Peak nasal inspiratory flow measurements: Utility for assessing nasal obstruction in children with rhinitis Source: Annual Congress 2010 - Paediatric asthma, rhinitis and management Year: 2010 FEV6 or FVC to detect airway obstruction in the community setting? Source: Annual Congress 2007 - PG17 - Lung function measurement in the community Year: 2007 The ratio of inspiratory ΣRrs to expiratory ΣRrs measured by forced oscillation technique correlates with the parameters reflecting narrowing of small airway measured by spirometry in patients with mild to moderate COPD Source: Annual Congress 2013 –New issues in lung function testing Year: 2013 Contribution of airway dimensions to severity of blood gas disturbances in patients with chronic airflow obstruction Source: Annual Congress 2009 - New data on respiratory function - from experimental approaches to man Year: 2009 The role of concomitant respiratory diseases on the rate of decline in FEV1 among adult asthmatics Source: Eur Respir J 2003; 21: 95-10 Year: 2003 Can the prediction point for FEV1 / FVC be determined in patients with insufficient expiratory maneuver to determine airflow obstruction? Source: Virtual Congress 2020 – Advances in lung function testing Year: 2020 Exercise-induced expiratory flow limitation and exercise capacity in patients with bronchial asthma Source: Eur Respir J 2002; 20: Suppl. 38, 290s Year: 2002 Detection of expiratory flow limitation during spontaneous breathing in patients with sarcoidosis Source: Eur Respir J 2004; 24: Suppl. 48, 224s Year: 2004 Maximal inspiratory and expiratory mouth pressures in children with mild bronchial asthma Source: Annual Congress 2012 - New insights in the physical assessment and therapy of respiratory patients Year: 2012