Source: Annual Congress 2009 - Prognosis and comorbidities in COPD
Disease area: Airway diseases

Abstract

AIM: To know whether COPD is an independent risk factor for coronary heart disease or whether this risk is related with an increased prevalence of classic risk factors.
METHODS: Cross-sectional study of cases (n = 116) and controls (n = 45). Inclusion criteria for cases were stable patients with ischemic heart disease (angina and myocardial infarction) and for controls, subjects with similar characteristics without history of ischemic heart disease. All of them underwent spirometry with a bronchodilator test, a standardized questionnaire and blood tests.
RESULTS: There were 94 men in the group of cases (76%) and 30 in control group (67%). The values of FEV1 postbroncodilatador were (mean + SD) 102.4% ± 19.7% in the case group and 104.6% ± 22.7% in the control group (p = 0.54). There were no significant differences between groups in weight, BMI index, smoking history, CRP, WBC, fibrinogen and homocysteine. Only abdominal perimeter was significantly higher in the case group (101cm ± 96cm ± 10 versus 12, P = 0006). In the univariate analysis OR (95%) value for sex was 1.21 (0.97 -1.52), COPD 0.7 (0.35 - 1.45), Mellitus Diabetes 1.84 (0 , 93 - 3.64), Dyslipidemia 1.47 (1.01 - 2.13), hypertension 1.35 (0.95 - 1.94), history of smoking as pack/years 1.61 (1.12 - 2 , 32) and overweight 1.13 (0.94 - 1.13). No significant impact of COPD was observed in multivariate analysis.
CONCLUSIONS: In our environment, chronic obstructive pulmonary disease does not increase the risk of ischemic heart disease. The higher prevalence of classic risk factors in patients with COPD may justify the higher incidence of ischemic heart disease in these patients.

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Citations should be made in the following way:
J. L. Izquierdo, A. Martinez, E. Guzman, B. Arnalich, C. Almonacid, P. Resano (Guadalajara, Spain). Chronic obstructive pulmonary disease does not increase the risk of ischaemic heart disease. Eur Respir J 2009; 34: Suppl. 53, 505

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