Source: Annual Congress 2009 - Prognosis and comorbidities in COPD
Disease area: Airway diseases

Abstract

The risk of death in patients with COPD is often graded with the use of a single physiological parameter, the FEV1. However, other risk factors can also associate with an increased risk of death.
We prospective study a cohort of 90 patients with COPD (age 54,99±0,87 yrs, 100% male), with we observed in period of 3-5 years. 78.9% of them was with severe COPD. There were 25 (27.8%) deaths over a mean follow-up period 42 months (range, 0.5 to 60). The majority of patients (88%) died of respiratory insufficiency and/or heart failure, 2 patients died of myocardial infarction, 1 patient of cancer.
The died patients were higher (p<0,05), had the large duration of dyspnoe (p<0.05), intensity and duration of smoking (p<0.01 and p<0.01). Also died patients had lower FEV1 (p<0.05), SaO2 (p<0.01) and more bad result of the 6-min walking test (p<0.001) then survival pts. The died patients had more expressed pulmonary hypertension (p<0.001), right ventricular (RV) hypertrophy (p<0.001) and dilatation (p < 0.001), right trial dilatation (p<0.05). At this category of the patients is more expressed RV diastolic dysfunction.
Thus, our data suggests that the risk factors of death of the patients with COPD are FEV1<40%, SaO2<90%, 6-minute walking test result< 300 M, pulmonary artery systolic pressure ≥40 mm Hg, RV wall ≥0,7 cm, RV diameter ≥ 3,0 cm, RV diastolic dysfunction, development of clinical symptoms of heart failure. The risk of death is higher at the elderly patients (>60 yrs) with dyspnoe duration > 10 yrs, duration of smoking >40 yrs, intensity of smoking ≥50 packs/years.

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Citations should be made in the following way:
N. Karoli, A. Rebrov (Saratov, Russian Federation). Risk factors of death in patients with COPD. Eur Respir J 2009; 34: Suppl. 53, 518

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