Source: Annual Congress 2006 - Sarcoidosis
Disease area: Interstitial lung diseases

Abstract

Introduction: Cardiac involvement in Sarcoidosis (SSar) manifests as myocardial fibrosis which increases tissue inhomogeneity with possible appearance of arrhythmias. Electrocardiographic markers, like maximum, minimum P wave and P wave dispersion {P_dis = P_max - P_min}can indicate patients prone to atrial arrhythmias. Aim of this study was the comparison of these indices in patients with SSar versus healthy control.
Methods: 90 patients with SSar (41 males,48±13 y.o., with disease duration 4.3±5.6 years) underwent digital electrocardiography (ECG), echocardiography and pulmonary function tests including spirometry, lung volume and diffusion capacity measurements. Diastolic and systolic indices of right and left ventricle were measured including Doppler parameters while Pmax, Pmin, Pdis and Standard Deviation of the RR duration(SDRR) were measured from ECG recording. Sixty five healthy subjects (30 males, 44±9 yo) were compared with SSar‘s group.
Results: Only ECG indices were significantly different compared to the patient group compared to controls (Pmax= 120±14 vs97±11 ms, p<0.0001, Pmin=76±12vs59±17 ms, p<0.0001, Pdis= 44±13 vs 38±10 ms, p<0.001). Pmax was correlated with SDRR (p<0.05, r=-0.272) and the age of the patients (p<0.05, r=0.219) while Pdis was correlated with SDRR(p<0.001, r=0.350) and the heart rate(p<0.005, r=0.323). Multivariate analysis showed that P max and Pdis were independently correlated with SDRR.
Conclusion: P wave indices were prolonged in SSar while Pmax and Pdis were negatively correlated with the SDRR, an index of heart rate variability implying imbalance of autonomic nervous system function.

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C. Floudas, A. Rapti, C. Kostopoulos, E. Gialafos, I. Moyssakis, E. Peros, R. Andrioti, V. Voteas, G. Pangalis, C. Stefanadis, G. Vaiopoulos (Athens, Greece). SARcoidosis cardiac study – P wave indices are increased in patients with systemic sarcoidosis. Eur Respir J 2006; 28: Suppl. 50, 3142

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