Source: Annual Congress 2006 - Sarcoidosis
Disease area: Interstitial lung diseases

Abstract

Interferon-α (IFN-α) is widely used for the treatment of chronic hepatitis C. Pulmonary side effects of IFN-α seem to be rare but a few cases of sarcoidosis in association with IFN-α treatment have been reported recently.
A 47 year old women with chronic hepatitis proven by biopsy due to hepatit C virus developed bilateral hilar lymphadenopathy on the 2nd month of the treatment with IFN-α.
Diagnosis of sarcoidosis was based on chest imaging studies,increased serum angiotensin converting enzyme levels, BAL findings and the histology of transbronchial biopsy with interstitial nonnecrotizing granulomas.Spontaneous remission was observed following IFN-α withdrawal.
Use of IFN-α in patients with chronic hepatitis C may trigger to development of sarcoidosis.Patients should be monitored during and following IFN-α therapy for the occurence of sarcoidosis.

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Citations should be made in the following way:
F. Kosar, S. Yurt, N. Isik, N. Yaman, P. Uysal (Istanbul, Turkey). Sarcoidosis associated with interferon-α therapy for chronic hepatitis C. Eur Respir J 2006; 28: Suppl. 50, 3128

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