Source: Annual Congress 2006 - Pulmonary hypertension: thromo-embolic processes
Disease area: Pulmonary vascular diseases

Abstract

Objective To observe the changing of D-Dimer before and after thrombolitic treatment of pulmonary thromboembolism (PTE), and to evaluate the value of the D-Dimer to the thrombolitic effect. Method Thrombolytic treatment with urokinase or rt-PA was used in 48 patients of acute massive and submassive PTE, D-Dimer was investigated before and right after, 24hr, 4d, 7d, 10d and 14d after thrombolitic treatment. Echocardiography, perfusion lung scan and CT angiography were performed before and 24hr, 14d after treatment, respectively. Results Before thrombolytic treatment, the level of D-Dimer (1.65±1.39mg/L ) was higher than normal (0.5mg/L), and went up right after thrombolytic treatment (4.94±3.04mg/L), then it went down after 24hr (3.04±2.71mg/L), but was higher than the level before thrombolitic treatment. After 7-14d treatment, it was lower than before. There was very small negative relationship between D-Dimer and the tricuspid regurgitation pressure gradient, and estimated pulmonary artery pressure ((r=-0.186, P=0.032 and r=-0.224, P=0.010, respectively). But there was no relationship between D-Dimer and the course of disease, the score of perfusion defect, and the score of CT embolism. Conclusions The level of D-Dimer before and after thrombolytic treatment reflected the status of emboli dissolution. It may be used to evaluate the thrombolytic effect.

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Citations should be made in the following way:
Y. Yang, Z. Zhai, X. Xu, C. Wang (Beijing, China). The changing of D-dimer in the thrombolytic process of pulmonary thromboembolism. Eur Respir J 2006; 28: Suppl. 50, 2366

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