Source: Annual Congress 2006 - Pulmonary hypertension: thromo-embolic processes
Disease area: Pulmonary vascular diseases

Abstract

Objectives In this case-control study, we aimed to determine the prevalence beta-fibrinogen gene -455G/A, -148C/T polymorphism in Chinese Han population and investigate whether they are associated with Pulmonary thromboembolism (PTE).
Methods The subjects consisted of 101 patients with PTE and 101 age and sex-matched healthy controls from the same geographic area. All patients were diagnosed by high probability of lung V/Q scan and/or multi-slice CTPA. Genotype and allele frequencies of fibrinogen beta gene -455G/A, -148C/T polymorphisms were examined by PCR-RFLP.
Results The allele frequencies G and A of fibrinogen beta –455 in the controls were 0.931,0.069 respectively,C and T of –148 were 0.777,0.223 respectively. There was significant difference of the -455G/A genotype frequencies distribution of AA, GA, GG between cases and in controls respectively, but no significant difference was found in the –148C/T polymorphisms.The frequencies of mutation allele -455A were 0.193,0.169 in cases and in controls respectively, p<0.05.while there was no statistically significant difference of –148T allele. The presence of A allele of fibrinogen beta –455 was found to be a greater risk factor for cases than in controls. No significant difference of –148A allele was found between the two groups.The relationship between -455G and -148C was partly concordant. There were close linkage equilibrium between -455G/A and –148C/T.
Conclusions: There is a complete linkage disequilibrium between fibrinogen beta -148C/T and -455G/A The frequencies of -455A, alleles in PTE were apparently higher than that of health adults. But there is no diferrence in -148T alleles.

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Citations should be made in the following way:
Z. Zhai, C. Wang, Y. Yang (Beijing, China). The relationship between polymorphisms of fibrinogen beta gene and pulmonary thromboembolism in Chinese Han population. Eur Respir J 2006; 28: Suppl. 50, 2358

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