Source: Annual Congress 2006 - Pulmonary hypertension: thromo-embolic processes
Disease area: Pulmonary vascular diseases

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) can be successfully treated by PEA but there are few prospective studies on long-term cardiopulmonary function, particularly on exertion. Between 1994 and 2006, 140 patients were treated with PEA at Pavia University Hospital; during the follow-up, 3 patients had a second PEA, 3 had transplant, and 27 died (16 within the first 3 months). In the table clinical and functional data of the 41 patients followed-up for at least 4 years (mean 5.5±1.3) are reported. Nearly all the improvement in hemodynamic, gas exchange and clinical status was achieved in the first 3 months and persisted at the end of follow-up. Vital capacity and distance at exercise testing further improved over time (post hoc analysis). In conclusion, in patients with CTEPH, persistent clinical and functional improvement can be achieved by PEA.

NYHA class and functional data* during the follow-up

	Before PTE	3 month	End of follow-up	ANOVA
NYHA class III-IV (%)	100	5	5
Distance at exercise testing (m)	195±171	455±278	636±339	p<0.0001
Cardiac output (L/min)	3.3±0.2	5.3±1.4	5.0±0.9	p<0.0001
mPAP (mmHg)	49±2	22±2	21±2	p<0.0001
PaO2st (mmHg)	55±2	73±2	73±2	p<0.0001
Vital capacity	91±3	90±2	95±2	p<0.05
DLco (% pred.)	69±3	72±3	69±3	NS

* Mean values and standard error

Rating:

Share or cite this content

Citations should be made in the following way:
I. Cerveri, A. G. Corsico, M. C. Zoia, R. Niniano, E. Ansaldo, P. M. Quaresima, A. M. D‘Armini, E. Pozzi, M. Viganò (Pavia, Italy). Long-term effects of pulmonary endarterectomy (PEA) on clinical and cardiopulmonary function status. Eur Respir J 2006; 28: Suppl. 50, 2357

Member's Comments

No comment yet.

Related content which might interest you: Long-term effects of pulmonary thromboendoarterectomy (PTE) on clinical and cardiopulmonary function status Source: Eur Respir J 2001; 18: Suppl. 33, 14s Year: 2001 The choice of priming solution for cardiopulmonary bypass during pulmonary endarterectomy for CTEPH patients has important impact Source: Virtual Congress 2021 – Thoracic surgery, lung cancer and complications of COVID-19 Year: 2021 Impact of preoperative pulmonary perfusion on lung function changes following cardiopulmonary bypass (CPB) and aortic clamping Source: Annual Congress 2007 - Clinical applications of lung function testing in children Year: 2007 The effect of coronary artery bypass surgery (CABS) on pulmonary function tests Source: Annual Congress 2010 - Respiratory system involvement in non-pulmonary disorders Year: 2010 Short-term exercise-based program associated to CPAP improves breathing pattern and functional status after coronary artery bypass graft surgery Source: Annual Congress 2013 –Long-term NIV: children, neuromuscular patients and technical aspects Year: 2013 Pre-operative anaemia does not influence clinical outcome in patients undergoing pulmonary endarterectomy (PEA) Source: International Congress 2016 – Special issues in thoracic surgery Year: 2016 Long-term outcomes of pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) Source: Eur Respir J 2007; 30: Suppl. 51, 603s Year: 2007 Evaluation of pulmonary function tests and respiratory muscle strength in geriatric patients who have undergone coronary artery bypass surgery Source: Eur Respir J 2005; 26: Suppl. 49, 497s Year: 2005 Short and long-term effects of pulmonary endarterectomy on ventilatory responses and exercise capacity of patients with chronic thromboembolic pulmonary hypertension Source: International Congress 2017 – The lungs and the heart during exercise Year: 2017 Impact of two 5-year anticoagulant strategies on survival and echocardiographic parameters in the patients with chronic thromboembolic pulmonary hypertension (CTEPH) who did not undergo pulmonary endarterectomy Source: Annual Congress 2004 - Pulmonary embolism Year: 2004 The impact of coronary artery bypass grafting on pulmonary function and pleural effusion occurrence with respect to the type of surgery: extracorporeal circulation versus beating heart Source: Eur Respir J 2004; 24: Suppl. 48, 173s Year: 2004 Late Breaking Abstract - Long-term outcome of perioperative extracorporeal membrane oxygenation (ECMO) in patients undergoing pulmonary endarterectomy (PEA). Source: International Congress 2017 – Outcomes and new treatment strategies in pulmonary hypertension Year: 2017 Exercise capacity and pulmonary artery pressure-flow relations in patients after successful pulmonary endarterectomy Source: Annual Congress 2009 - Acute and chronic venous thromboembolic disease Year: 2009 Long-term effects of cardiac rehabilitation on sleep apnea severity in patients with coronary artery disease Source: International Congress 2017 – CPAP therapy Year: 2017 An audit of adverse events during pulmonary function testing (PFT) and cardiopulmonary exercise testing (CPEX) in pre-operative abdominal aortic anuerysm (AAA) patients Source: Annual Congress 2013 –Reference, reliability and risk: advances in lung function Year: 2013 Right ventricular function and exercise capacity in response to successful pulmonary endarterectomy surgery Source: International Congress 2016 – Pulmonary hypertension and chronic thromboembolic pulmonary hypertension Year: 2016 Initial dual oral combination therapy prior to pulmonary endarterectomy (PEA) in patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) and high preoperative pulmonary vascular resistance (PVR) Source: Virtual Congress 2020 – Chronic thromboembolic pulmonary hypertension Year: 2020 Comparison of cardiopulmonary exercise test in COPD patients with and without coronary artery disease Source: Annual Congress 2013 –The best posters in exercise testing and physical inactivity Year: 2013 Additive effects of balloon pulmonary angioplasty and the following cardiac rehabilitation on exercise capacity and quality of life Source: International Congress 2015 – Pulmonary circulation: the story of fresh and old clots Year: 2015 Effects of eight weeks long supervised exercise training on exercise capacity and pulmonary function in patients after coronary artery bypass surgery Source: International Congress 2018 – Chronic lung disease : effects of rehabilitation interventions on functional outcomes in patients Year: 2018