Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation

W. Matsuyama, M. Watanabe, R. Hirano, H. Mitsuyama, I. Higashimoto, M. Osame, K. Arimura (Kagoshima, Japan)

Source: Annual Congress 2006 - Cellular immunology in asthma pathogenesis
Session: Cellular immunology in asthma pathogenesis
Session type: Oral Presentation
Number: 2155
Disease area: Interstitial lung diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
W. Matsuyama, M. Watanabe, R. Hirano, H. Mitsuyama, I. Higashimoto, M. Osame, K. Arimura (Kagoshima, Japan). Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation. Eur Respir J 2006; 28: Suppl. 50, 2155

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Selective decoy-mediated inhibition of activator protein-1 activity in the airways prevents experimental asthmatic inflammation
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


The epidermal growth factor receptor mediates allergic airway remodelling in the rat
Source: Eur Respir J 2008; 32: 1213-1223
Year: 2008



Decreased PTEN amplifies PI3K signaling and enhances pro-inflammatory cytokine release in COPD
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016

The pronounced high expression of discoidin domain receptor 2 in human interstitial lung diseases
Source: ERJ Open Res, 4 (1) 00138-2016; 10.1183/23120541.00138-2016
Year: 2018



Bile acid receptor accelerates to the lung cancer process induced by lung fibroblast-tumor cells interaction, with high activation of phosphorylated STAT3 and alteration of cytokine secretion
Source: International Congress 2017 – Lung cancer - basic science: the latest results from the bench
Year: 2017

Toll like receptor 4 activation upregulates miR-181b attenuating pulmonary fibrosis via targeting TGFBR1
Source: International Congress 2015 – Latest news on miRNAs in pulmonary research
Year: 2015



CCL5 (RANTES) inhibits TGF-β1-induced collagen production in human bronchial epithelial cells by action of Smad protein
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

Remicade suppresses cytokine-induced up-regulation of bradykinin receptor-mediated airway smooth muscle contractions
Source: Annual Congress 2005 - Inflammation and the airway smooth muscle: cellular and pharmacological interactions
Year: 2005


The pattern recognition receptor Nod1 activates CCAAT/enhancer binding protein β signalling in lung epithelial cells
Source: Eur Respir J 2007; 30: 214-222
Year: 2007



Composition of the cellular matrix, nutrition, and hypoxia modulate the secretion and activation of collagenases and their inhibitors in human lung cells
Source: Eur Respir J 2001; 18: Suppl. 33, 244s
Year: 2001

Human airway epithelial cell stimulation causes IL-8 expression via a PKC-TACE-EGFR-MEK pathway
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Enhanced expression of Fas ligand (FasL) in fibrotic interstitial lung diseases (ILDs). The possible role of membrane-bound FasL form
Source: Annual Congress 2011 - Genetic and molecular background in pulmonary fibrosis
Year: 2011


Activation of TLR3 augments myofibroblasts differentiation and extracellular matrix production
Source: Annual Congress 2009 - Lung cell biology and immunology
Year: 2009



Surfactant protein A modulate bleomycin-induced lung injury in toll-like receptor 2 dependent pathway
Source: Annual Congress 2010 - Determinants of acute lung injury and fibrosis
Year: 2010

Vitamin E down-modulates activation of NFκB, secretion of IL-8 and expression of cell adhesion molecules in lung epithelial cells
Source: Eur Respir J 2002; 20: Suppl. 38, 620s
Year: 2002

Egr-1 regulates muc5ac expression through activator protein-1 (AP-1) in chronic airway inflammation diseases
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


Oral Presentation: The functional role of the Frizzled-8 receptor TGF-beta1-induced activation and extracellular matrix production in human lung fibroblasts
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Growth hormone releasing hormone-receptor antagonist MIA-602 modulates lung inflammation, cellular signal transduction, and promotes apoptosis of mouse lung fibroblasts
Source: Virtual Congress 2020 – Translational therapeutic advances
Year: 2020


Transforming growth factor-β inhibition of lung fibroblast proliferation is mediated through prostaglandin E2, via activation of p38 mitogen-activated protein kinase
Source: Annual Congress 2005 - Pulmonary hypertension and fibrosis: novel mechanisms
Year: 2005