Source: Annual Congress 2006 - COPD and inflammation
Disease area: Airway diseases

Abstract

Introduction
Elevation of C-reactive protein (CRP) has been associated to several comorbidities including COPD and ischemic heart disease(IHD). We observed, in a group of individuals from general population, wide range of CRP levels not explained by comorbidities and decided to study the CRP association with respiratory clinical outcomes.
Methods:
Individuals without lung disease, recent cardiovascular events, malignancies or chronic inflammatory conditions, performed complete pulmonary function test, six minute walk test (6MWT), St George Respiratory Questionnaire and a cardiopulmonary exercise test to exclude subclinical IHD. High sensitivity CRP was also measured. Patients were divided in 2 groups: high CRP (HCRP) (>3 mg/L) and normal CRP(NCRP) (3 or less mg/L) following guidelines.We used Student‘s t test to determine the difference between groups and multivariate analyses to detect predictors of CRP values.
Results:
There were sixty seven individuals (63% men) with mean age (SD) 64 (6) years. Subjects in the HCRP group (n=25; CRP GeomMean, SD = 6.10, 1.58 mg/L) walked less (517 vs 568 m, p<0,03) and had a higher BMI (29.4 vs 26.1Kg/m²)compared to NCRP group (n=42; CRP GeomMean, SD = 0.96,1.93) . Multivariate regression analysis showed an association between HCRP and lower FEV₁(L), lower 6MWT, higher BMI, male gender and higher age.
Conclusions:
CRP elevation is associated to lower pulmonary function test and reduced exercise performance in a sample of general population with limited comorbidity. These findings may be related to an underlying " inflammatory phenotype" and not to specific comorbid conditions.

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Citations should be made in the following way:
V. M. Pinto-Plata, H. Mullerova, B. R. Celli (Boston, United States Of America; London, United Kingdom). Elevated C-reactive protein is associated with reduced lung function and exercise capacity in normal subjects. Are we born inflammed?. Eur Respir J 2006; 28: Suppl. 50, 1994

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