Source: Annual Congress 2006 - Pneumonia and other invasive pulmonary infections in children
Disease area: Interstitial lung diseases, Respiratory infections

Abstract

Cytomegalovirus (CMV) pneumonitis is associated with high rates of morbidity and mortality. The diagnosis of CMV pneumonitis is based on the precence of signs and symptoms of lower respiratory tract infection and diffuse infiltrates on a chest radiography and identification of CMV in bronchoalveolar lavage (BAL) fluid.
Aim: Usage of BAL fluid in diagnosis and treatment of immunocompetant children who were thought viral pneumonitis with clinical and radiological findings.
Method: CMV viral load by PCR was performed in BAL fluid in 40 patients who had wheezing and diffuse infiltrates on chest radiographies or mozaic pattern in thorax CT.
Results:. CMV viral load in BAL fluid was found high in 10 patients (%25). CMV viral load in BAL fluid in these 10 patients changed between 2270 and 1050000 and mean value was 167637. Two of them had high CMV viral load in their urine only and other two patients had serum CMV Ig M positivity and high viral load in urine also. All patients treated with 10mg/kg ganciclovir for 21 days. Three patients‘ clinical findings improved in 10 days and radiologic findings improved on their control visit. Other patients‘ symptoms regressed with therapy.
Conclusions: Determination of CMV viral load in BAL is more sensitive than blood.In patients who hadn‘t immune deficiency wheezing could disappear with ganciclovir treatment.

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Citations should be made in the following way:
S. Pekcan, N. Cobanoglu, E. Yalcin, D. Dogru, U. Ozcelik, N. Kiper (Ankara, Turkey). Diagnosis of CMV pneumonitis from bronchoalveolar lavage fluid of a wheezy infant. Eur Respir J 2006; 28: Suppl. 50, 1794

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