Source: Annual Congress 2008 - Mediastinal lesions; rare pathology
Disease area: Thoracic oncology

Abstract

The aim of our investigation is to present our experience in the diagnosis and treatment of patients with mediastinal angiofolicular lymphoid hyperplasia – Castleman‘s disease.
Methods: Six patients with proved Castleman disease have been operated in Thoracic Surgery Department for a period of 25 years. All patients are with CT verified mediastinal tumor masses and they have undergone fibrobronchoscopy, I¹³¹ scintigraphy, electromyography, blood gas analysis, and functional examination of breathing. The intraoperative biopsy material is immediately histologically examined. The patients have been followed for 4 to 23 years.
Results: All the patients have been estimated as suitable for radical surgical extirpation of mediastinal masses on the base of complex preoperative and intraoperative tests. According to the localization in 5 patients we performed thoracotomy and in 1 patient sternotomy. Extirpated tumor masses are well capsulated, vascularised, with the size ranging from 3/5 to 10/15 cm. All are diagnosed as hyaline vascular variant of Catleman‘s disease by pathological examination. There aren‘t any postoperative complication and the follow up study does not establish recurrence of the disease.
Conclussion: As the radical extirpation is with excellent remote results, surgical resection of the tumor is the first choice of treatment of localized mediastinal forms of Catleman‘s disease.

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Citations should be made in the following way:
D. Petrov, R. Petkov, V. Vlasov, T. Minchev, Y. Steneva (Sofia, Bulgaria). Our experience with mediastinal localized form of Castleman disease. Eur Respir J 2008; 32: Suppl. 52, 2147

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