Source: Annual Congress 2006 - Pneumonia and other invasive pulmonary infections in children
Disease area: Paediatric lung diseases, Respiratory infections

Abstract

Simkania negevensis is a Chlamydia-like intracellular, penicillin-resistant microrganism that has been associated with a variety of respiratory illnessess both in adult and children. We conducted a prospective study during a 15-month period enrolling 101 children (4.7±3.4 yrs) with community-acquired pneumonia (CAP). On admission, all patients underwent a clinical evaluation, blood samples and chest radiograph. Serum samples for serologic assays were obtained on admission and an average of 35 days later. There was serological evidence for acute infection with S. negevensis in 14 children (14%): 5 infections were single and 9 were mixed with other agents (4 with M. pneumoniae, 1 with S. pneumoniae and 3 with viruses). The most frequent pathogen found was M. pneumoniae (27%), followed by S. pneumoniae (18%). Considering only single infections, the median age of S. negevensis, M. pneumoniae and S. pneumoniae-positive patients was 60 months, 82 months and 56 months, respectively. C-reactive protein, ESR and procalcitonin were 89.1 mg/l, 57.4 mm/h and 5.3 ng/ml in S. negevensis-positive patients, 183.4 mg/l, 83.6 mm/h and 12.9 ng/ml in M. pneumoniae-positive patients and 163.6 mg/l, 77.2 mm/h and 18 ng/ml in S. pneumoniae-positive patients, respectively. Chest X-rays showed interstitial findings in 50% of Simkania infected children and no complications occurred in these patients. Despite no previously reported co-infections with other atypical pathogens, we found that nearly 30% (28.5%) of Simkania positive patients were co-infected with M. pneumoniae. Our study demonstrates the relatively high prevalence of Simkania infection and the involvement of this microrganism in pediatric CAP.

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L. Fasoli, M. Don, M. Paldanius, M. Korppi, M. Canciani (Udine, Italy; Oulu, Kuopio, Finland). Simkania negevensis and community-acquired pneumonia: a pediatric survey. Eur Respir J 2006; 28: Suppl. 50, 1784

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