Source: Annual Congress 2008 - Physiological response to exercise performance

Abstract

Background: To investigate peripheral muscle dysfunction and benefits of exercise training in lung transplant recipients (LTR).
Methods: Twelve LTR and 7 age-matched control subject (C) underwent 3-month home-based endurance training. According to time post transplantation, LTR were divided in short-term (ST < 25 month, n = 7) or long-term (LT > 50 month, n = 5) subgroup. Measurements were biopsy of the vastus lateralis, quadriceps twitch tension (Twq), maximal incremental and constant-workload cycling exercise and Chronic Respiratory Questionnaire (CRQ).
Results: Percentage of type I fibers (%fbI), Twq and maximal oxygen consumption (VO_2peak) were lower in LTR than C (p < 0.03). In LTR, %fbI was lower in LT vs. ST (12 ± 4 vs. 19 ± 6%, p = 0.05) and Twq independently related to VO_2peak (r = 0.72, p = 0.04). After training, Twq and dyspnea score (CRQ) were increased in both subgroups and their respective improvements were associated (r = 0.74, p = 0.04). However, greater increases in exercise capacity were observed in ST vs. LT in VO_2peak (+27 ± 25 vs. -0 ± 17 % of baseline, respectively, p = 0.04) and endurance time (+17 ± 9 vs. +4 ± 10 min, respectively, p = 0.09). In LTR, the lower initial %fbI, the lower gain in endurance time was reported after training (r = 0.70, p = 0.03).
Conclusions: Significant peripheral muscle dysfunction persists after pulmonary transplantation which affects fiber type‘s composition, peripheral muscle strength and exercise capacity. Four years after transplantation, at comparable pulmonary function, LTR had worse muscle function and lower ‘trainability‘ than LTR in the first 2 years.

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I. Vivodtzev, C. Pison, P. Mezin, K. Guerrero, E. Maclet, J. C. Borel, R. Hacini, O. Chavanon, P. Lévy, B. Wuyam (Grenoble, St Julien de Ratz, France). Muscle function and trainability of lung transplantation recipients. Eur Respir J 2008; 32: Suppl. 52, 3301

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