Roles of Rho-Rock and Smad pathways in TGFβ1-mediated lung fibroblast differentiation

D. Yang, T. Wu, H. Xie (Shanghai, Dalian, China)

Source: Annual Congress 2008 - Regulatory mechanisms of cell activation, renewal and recruitment
Session: Regulatory mechanisms of cell activation, renewal and recruitment
Session type: Thematic Poster Session
Number: 693

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Yang, T. Wu, H. Xie (Shanghai, Dalian, China). Roles of Rho-Rock and Smad pathways in TGFβ1-mediated lung fibroblast differentiation. Eur Respir J 2008; 32: Suppl. 52, 693

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Activation of WNT co-receptor LRP5  is required for WNT and TGF-ß1 induced fibroblast activation
Source: Virtual Congress 2020 – Physiological and cellular mechanisms affecting pulmonary pathologies
Year: 2020


Wnt and TGF-beta signaling in lung development
Source: Lung Science Conference 2009 - Cell proliferation, Differentiation and Carcinogenesis
Year: 2009



Involvement of Hedgehog pathway in airway cell differentiation
Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases
Year: 2018




YI02 - Activation of Wnt/beta-catenin signaling promotes lung epithelial repair in emphysema
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

Hedgehog signalling crosstalks orchestrate human lung development
Source: Virtual Congress 2020 – Cellular stress in respiratory diseases
Year: 2020


WNT5A antagonizes canonical WNT/beta-catenin signaling in lung epithelial cells
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Placenta growth factor promotes autophagy in lung epithelial cell through JNK and p38 MAPK pathway
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Cell cycle regulation of IPF-derived lung fibroblasts is dependent on RhoA signalling
Source: Eur Respir J 2005; 26: Suppl. 49, 102s
Year: 2005

BMP-Smad1 target gene Wnt inhibitory factor 1 (WIF1) coordinates BMP and Wnt signaling activities in regulating lung development in vivo
Source: Annual Congress 2010 - New mechanisms in lung development, acute and chronic lung diseases
Year: 2010

PP222 – Forkhead Box F1 as a mediator of Wnt signaling in human lung endothelial cells
Source: ERS Lung Science Conference 2021
Year: 2021

Leptin activates the JAK/STAT signaling pathway in bronchial and alveolar epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 338s
Year: 2006

Differential role of EPAC and PKA in the transduction of cAMP-mediated inhibition of human lung fibroblast proliferation and collagen synthesis
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


TGFβ induced myofibroblast differentiation is independent of p38 activation, but requires TGFβR1 kinase activity and correlates with TGFβ-mediated SMAD signaling and TGFβ-responsive gene expression patterns in human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 718s
Year: 2004

HMGA2 mediated epigenetic regulation of Gata6 controls epithelial WNT signaling during lung development
Source: International Congress 2017 – Molecular biology of normal and abnormal lung development
Year: 2017

Inhibition of VEGF blocks TGF-β1 production through a PI3K/Akt signalling pathway
Source: Eur Respir J 2008; 31: 523-531
Year: 2008



Promotion of pulmonary fibroblast migration by bile acid receptor through activation of TGF-ß1/p-Smad3 signaling pathway
Source: International Congress 2018 – Novel insights in the basic and translational research on idiopathic interstitial pneumonias
Year: 2018

A critical role for mTOR regulated metabolic reprogramming during TGF-? induced fibroblast collagen synthesis
Source: ERS Lung Science Conference 2017
Year: 2017

A549 cell promotes the proliferation and migration of fibroblast through FXR pathway
Source: International Congress 2019 – Biology of lung cancer
Year: 2019