Source: Annual Congress 2008 - Physiological response to exercise performance
Disease area: Airway diseases

Abstract

Physical activity can be related to inflammatory response.The purpose of this study was to evaluate the relationship between cytokine release and short–term or long-term exercise in patients with COPD.We included eighteen male patients with moderate to severe COPD:eleven patients were enrolled in an eight-week pulmonary rehabilitation (PR) program and seven sedentary patients were included as control.All patients performed spirometry and endurance exercise test (60% of CPET maximal load) before and after PR (ET1;ET2).Blood sample was obtained at baseline and after the endurance test, pre and post PR.Plasma interleukins-IL-1 beta,IL-6 and Tumor Necrosis Factor-alfa concentrations were measured by ELISA(Quantikine^®,R&D Systems).Cytokine release was controlled for COPD exacerbation during PR.IL-1b release was significantly lower in PR group after training (PR group:ET1 3.45±0.85,ET2 2.30±0.62 pg/ml;control group:ET1 3.65±0.75,ET2 2.87±0.54 pg/ml;p=0.03).There were no differences in IL-6 release after training (PR group:ET1 9.58±1.10(mean±SE),ET2 8.83±1.10 pg/ml;control group:ET1 7.42±1.86,ET2 7.05±0.97 pg/ml;p=0.68).Only five patients (all with COPD exacerbation,four in PR group) released TNF-a and exercise did not change TNF-a concentrations (PR group:ET1 2.86±1.18,ET2 2.57±1.37pg/ml;control group:ET1 4.98,ET2 6.84 pg/ml;p=0.14).Exercise intensity was not associated with cytokine release(p>0.05).COPD exacerbation increased IL-6 ET2 levels (9.59±1.32 pg/ml versus 6.31±0.92 pg/ml;p=0.03) and did not change IL-1b ET2 levels (3.13±0.66 pg/ml vs 1.75±0.33 pg/ml;p=0.06).We concluded that PR decreases IL-1b release and COPD exacerbation stimulates IL-6 and TNF-a release.

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D. Chiesa, M. Knorst, R. Pinho, K. Mezzomo (Porto Alegre/RS, Brazil). Release of IL-1b, IL-6 and TNF-a after pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. Eur Respir J 2008; 32: Suppl. 52, 3286

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